SETD1A

Gene Symbol SETD1A
Entrez Gene 9739
Alt Symbol KMT2F, Set1, Set1A
Species Human
Gene Type protein-coding
Description SET domain containing 1A
Other Description SET domain-containing protein 1A|hSET1A|histone-lysine N-methyltransferase SETD1A|lysine N-methyltransferase 2F|set1/Ash2 histone methyltransferase complex subunit SET1
Swissprots O15047 A6NP62 Q8TAJ6 Q6PIF3
Accessions CCO13810 O15047 AB002337 BAA20797 BC027450 AAH27450 BC035795 AAH35795 XM_005255723 XP_005255780 XM_006721106 XP_006721169 XM_011545994 XP_011544296 XM_011545995 XP_011544297 XM_011545996 XP_011544298 NM_014712 NP_055527
Function Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. {ECO:0000269|PubMed:12670868}.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
Top Pathways Lysine degradation

Set1A (N-17) - sc-83475 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-hSET1 antibody - ab70379 from Abcam

Prices $379.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Lanes 1 - 4 : Anti-hSET1 antibody (ab70379) at 1 µg/mlLanes 5 - 8 : Anti-hSET1 antibody (ab70379) at 0.2 µg/mlLane 1 : 293T whole cell lysate at 100 µgLane 2 : 293T whole cell lysate at 200 µgLane 3 : 293T nuclear lysate at 100 µgLane 4 : 293T nuclear lysate at 200 µgLane 5 : 293T whole cell lysate at 100 µgLane 6 : 293T whole cell lysate at 200 µgLane 7 : 293T nuclear lysate at 100 µgLane 8 : 293T nuclear lysate at 200 µgdeveloped using the ECL technique

Anti-hSET1 antibody - ab84510 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84510 at 1/250 dilution staining hSET1 in Human breast adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-hSET1 antibody - ChIP Grade - ab70378 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling hSET1 with ab70378 at 1/1000 (1µg/ml). Detection: DAB.

Anti-hSET1 antibody - N-terminal - ab174866 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-hSET1 antibody - N-terminal (ab174866) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-SETD1A / SET1 Antibody (aa900-950) - LS-C68249 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa1200-1250) - LS-C68250 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa927-956, Biotin) - LS-C269070 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa927-956, FITC) - LS-C269071 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa927-956, AP) - LS-C269067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa927-956, APC) - LS-C269069 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa927-956, PE) - LS-C269073 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa927-956, Azide-free, HRP) - LS-C269072 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (C-Terminus) - LS-C287196 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa927-956) - LS-C156050 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SETD1A Antibody western blot of 293 cell line lysates (35 ug/lane). The SETD1A antibody detected the SETD1A protein (arrow).

Anti-SETD1A / SET1 Antibody (aa927-956) - LS-C325027 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (N-Terminus) - LS-C347715 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD1A / SET1 Antibody (aa900-950) - LS-C287194 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human hSET1 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-hSET1 used at a dilution of 1:1000 (1 Detection: DAB.

Anti-SETD1A / SET1 Antibody (aa1-320, clone 7B7) - LS-C339748 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B7
IHC of paraffin-embedded Human tonsil using anti-SETD1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-SETD1A / SET1 Antibody (aa1330-1379) - LS-C205711 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SETD1A / SET1 antibody Western Blot of Breast Tumor. Antibody dilution: 1 ug/ml.

Anti-SETD1A / SET1 Antibody (aa1200-1250) - LS-C286430 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse hSET1 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-hSET1 used at a dilution of 1:250.

Anti-SETD1A / SET1 Antibody (aa1-320, clone 1D3) - LS-C339596 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SETD1A (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SETD1A.

Anti-SETD1A / SET1 Antibody (aa1200-1250) - LS-C287195 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human hSET1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-hSET1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

SETD1A Antibody - NB100-558 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SETD1A Antibody [NB100-558] - Detection of Human hSET1 by Western Blot. Samples: Nuclear extract (50, 15, 5 ug) from 293T cells. Antibody: Affinity purified rabbit anti-hSET1 antibody NB100-558 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

SETD1A Antibody - NB100-557 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: SETD1A Antibody [NB100-557] - Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-hSET1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
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