Gene Symbol | MEGF11 |
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Entrez Gene | 84465 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | multiple EGF-like-domains 11 |
Other Description | multiple EGF-like domains protein 11|multiple epidermal growth factor-like domains protein 11 |
Swissprots | Q6UXS5 Q17R86 A6BM72 Q96KG6 Q8ND91 |
Accessions | A6BM72 EAW77754 EAW77755 EAW77756 EAW77757 AB058677 BAB47410 AB300051 BAF64841 AK090663 AL834326 CAD38994 AY358226 AAQ88593 BC029999 BC117419 AAI17420 BC126313 AAI26314 XM_011522109 XP_011520411 NM_032445 NP_115821 |
Function | May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17498693}; Single-pass type I membrane protein {ECO:0000269|PubMed:17498693}. Basolateral cell membrane {ECO:0000269|PubMed:17498693}; Single- pass type I membrane protein {ECO:0000269|PubMed:17498693}. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10. |
MEGF11 CRISPR/Cas9 KO Plasmid (h) - sc-413651 from Santa Cruz Biotechnology
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MEGF11 HDR Plasmid (h) - sc-413651-HDR from Santa Cruz Biotechnology
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MEGF11 Double Nickase Plasmid (h) - sc-413651-NIC from Santa Cruz Biotechnology
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MEGF11 Double Nickase Plasmid (h2) - sc-413651-NIC-2 from Santa Cruz Biotechnology
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MEGF11 CRISPR Activation Plasmid (h) - sc-413651-ACT from Santa Cruz Biotechnology
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MEGF11 CRISPR Activation Plasmid (h2) - sc-413651-ACT-2 from Santa Cruz Biotechnology
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MEGF11 Lentiviral Activation Particles (h) - sc-413651-LAC from Santa Cruz Biotechnology
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MEGF11 Lentiviral Activation Particles (h2) - sc-413651-LAC-2 from Santa Cruz Biotechnology
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MEGF11 siRNA (h) - sc-89997 from Santa Cruz Biotechnology
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MEGF11 shRNA Plasmid (h) - sc-89997-SH from Santa Cruz Biotechnology
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MEGF11 shRNA (h) Lentiviral Particles - sc-89997-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN13192 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13192 from Sigma-Aldrich
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MEGF11 siRNA (Human) - CRJ3491 from Cohesion Biosciences
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Human MEGF11 siRNA - orb273992 from Biorbyt
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MEGF11 shRNA Plasmid (Human) - CHJ3491 from Cohesion Biosciences
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MEGF11 miRNA 3'UTR clone - MiUTR4H-TG05460 from Creative biogene
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