CYFIP1

Gene Symbol CYFIP1
Entrez Gene 23191
Alt Symbol P140SRA-1, SHYC, SRA-1, SRA1
Species Human
Gene Type protein-coding
Description cytoplasmic FMR1 interacting protein 1
Other Description cytoplasmic FMR1-interacting protein 1|cytoplasmic FMRP interacting protein 1|selective hybridizing clone|specifically Rac1-associated protein 1
Swissprots Q6ZSX1 Q14467 A8K6D9 Q5IED0 Q9BVC7 Q7L576 Q9BSD9
Accessions EAW65555 Q7L576 AK024816 AK125784 BAG54247 AK125936 BAG54268 AK127094 BAC86825 AK291604 BAF84293 AL357618 AY763577 AAW51476 AY763578 AAW51477 AY763579 AAW51478 AY763580 AAW51479 BC001306 AAH01306 BC005097 AAH05097 BC063869 BF979687 D38549 BAA07552 DA317955 DQ896439 ABM87438 EU176439 ABW03890 KJ534819 AHW56459 XM_011543873 XP_011542175 XM_011543874 XP_011542176 XM_011543875 XP_011542177 XM_011543876 XP_011542178 NM_001033028 NP_001028200 NM_001287810 NP_001274739 NM_014608 NP_055423
Function Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. {ECO:0000250, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}.
Top Pathways RNA transport, Regulation of actin cytoskeleton

CYFIP1 (T-20) - sc-49935 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CYFIP1 (T-20): sc-49935. Western blot analysis of CYFIP1 expression in non-transfected 293T: sc-117752 (A), human CYFIP1 transfected 293T: sc-171687 (B) and HeLa (C) whole cell lysates.

CYFIP1 (N-14) - sc-49934 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CYFIP1 (N-14): sc-49934. Western blot analysis of CYFIP1 expression in HeLa whole cell lysate.

CYFIP1 (D-15) - sc-49932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CYFIP1 (D-15): sc-49932. Western blot analysis of CYFIP1 expression in non-transfected 293T: sc-117752 (A), human CYFIP1 transfected 293T: sc-171687 (B) and HeLa (C) whole cell lysates.

CYFIP1/2 (H-300) - sc-134440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-CYFIP1 antibody - ab108220 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CYFIP1 antibody (ab108220) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-CYFIP1 antibody - ab99460 from Abcam

Prices $368.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CYFIP1 antibody [EPR10782] - ab156016 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10782
All lanes : Anti-CYFIP1 antibody [EPR10782] (ab156016) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : A549 cell lysateLane 4 : Fetal brain lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CYFIP1 antibody - N-terminal - ab154045 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CYFIP1 antibody - N-terminal (ab154045) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-CYFIP1 Antibody (Internal) - LS-C108911 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-CYFIP1 Antibody (aa1159-1208) - LS-C151744 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYFIP1 antibody Western Blot of COLO205.

Anti-CYFIP1 Antibody (aa361-410) - LS-C187331 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Human ACHN. CYFIP1 antibody dilution 1.0 ug/ml.

Anti-CYFIP1 Antibody (aa1203-1253) - LS-C289702 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human CYFIP1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-CYFIP1 antibody used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. CYFIP1 was also immunoprecipitated by rabbit anti-CYFIP1 antibody BL10812, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).

CYFIP1 Antibody - NBP2-16060 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYFIP1 Antibody [NBP2-16060] - Sample (30 ug of whole cell lysate) A: HeLa 5% SDS PAGE gel, diluted at 1:1000.

CYFIP1 Antibody - NBP1-50028 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYFIP1 Antibody [NBP1-50028] - Detection of Human CYFIP1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-CYFIP1 antibody used for WB at 0.4 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. CYFIP1 was also immunoprecipitated by rabbit anti-CYFIP1 antibody BL10812, which recognizes an upstream epitope. For blotting immunoprecipitated CYFIP1, the ReliaBLOT. Reagents and Procedures were used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).

CYFIP1 Antibody - NBP1-46121 from Novus Biologicals

Prices $199.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CYFIP1 (N-terminal) antibody produced in rabbit - SAB2700152 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CYFIP1 (N-terminal): <B>Cat. No. SAB2700152</B>: Immunohistochemical analysis of paraffin-embedded Hepatoma, using CYFIP1 antibody at 1:500 dilution.

CYFIP1 Antibody - C-terminal region (ARP64537_P050) - ARP64537_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYFIP1-Antibody-internal-region - AF3040a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

CYFIP1 antibody [N1N2], N-term - GTX122467 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-CYFIP1 antibody [N1N2], N-term used in ICC/IF. GTX122467

CYFIP1 antibody, Internal - GTX88307 from GeneTex

Prices $239.00
Sizes 100 μg
Host Goat
Clonality Polyclonal

CYFIP1 Antibody (OAEB00327) - OAEB00327 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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