| Gene Symbol |
CYFIP1
|
| Entrez Gene |
23191
|
| Alt Symbol |
P140SRA-1, SHYC, SRA-1, SRA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytoplasmic FMR1 interacting protein 1
|
| Other Description |
cytoplasmic FMR1-interacting protein 1|cytoplasmic FMRP interacting protein 1|selective hybridizing clone|specifically Rac1-associated protein 1
|
| Swissprots |
Q6ZSX1 Q14467 A8K6D9 Q5IED0 Q9BVC7 Q7L576 Q9BSD9
|
| Accessions |
EAW65555 Q7L576 AK024816 AK125784 BAG54247 AK125936 BAG54268 AK127094 BAC86825 AK291604 BAF84293 AL357618 AY763577 AAW51476 AY763578 AAW51477 AY763579 AAW51478 AY763580 AAW51479 BC001306 AAH01306 BC005097 AAH05097 BC063869 BF979687 D38549 BAA07552 DA317955 DQ896439 ABM87438 EU176439 ABW03890 KJ534819 AHW56459 XM_011543873 XP_011542175 XM_011543874 XP_011542176 XM_011543875 XP_011542177 XM_011543876 XP_011542178 NM_001033028 NP_001028200 NM_001287810 NP_001274739 NM_014608 NP_055423
|
| Function |
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. {ECO:0000250, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}.
|
| Top Pathways |
RNA transport, Regulation of actin cytoskeleton
|