CYFIP1

Gene Symbol	CYFIP1
Entrez Gene	23191
Alt Symbol	P140SRA-1, SHYC, SRA-1, SRA1
Species	Human
Gene Type	protein-coding
Description	cytoplasmic FMR1 interacting protein 1
Other Description	cytoplasmic FMR1-interacting protein 1|cytoplasmic FMRP interacting protein 1|selective hybridizing clone|specifically Rac1-associated protein 1
Swissprots	Q6ZSX1 Q14467 A8K6D9 Q5IED0 Q9BVC7 Q7L576 Q9BSD9
Accessions	EAW65555 Q7L576 AK024816 AK125784 BAG54247 AK125936 BAG54268 AK127094 BAC86825 AK291604 BAF84293 AL357618 AY763577 AAW51476 AY763578 AAW51477 AY763579 AAW51478 AY763580 AAW51479 BC001306 AAH01306 BC005097 AAH05097 BC063869 BF979687 D38549 BAA07552 DA317955 DQ896439 ABM87438 EU176439 ABW03890 KJ534819 AHW56459 XM_011543873 XP_011542175 XM_011543874 XP_011542176 XM_011543875 XP_011542177 XM_011543876 XP_011542178 NM_001033028 NP_001028200 NM_001287810 NP_001274739 NM_014608 NP_055423
Function	Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. {ECO:0000250, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}.
Top Pathways	RNA transport, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CYFIP1 protein fragment - ab153207 from Abcam Category Protein Source Wheat germ Species Human

CYFIP1 Antibody Blocking Peptide - LS-E23647 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYFIP1 Antibody Blocking Peptide - LS-E23526 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYFIP1 Antibody Blocking Peptide - LS-E27198 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CYFIP1 Protein - H00023191-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CYFIP1-Antibody-C-term-Blocking-Peptide - BP17497b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CYFIP1 blocking peptide - GTX88307-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

CYFIP1 Immunizing peptide - orb17862 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

SRA1 protein (His tag) - 80R-2574 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

CYFIP1 Blocking Peptide - abx161072 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig, Zebrafish

CYFIP1 Peptide - AC21-2018-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CYFIP1 - H00023191-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CYFIP1 - H00023191-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CYFIP1 Peptide - 42-242P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

CYFIP1 fusion protein - ag8090 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CYFIP1 Blocking Peptide - CBP3571 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Pig, Zebrafish

Recombinant Human Cytoplasmic FMR1-interacting protein 1(CYFIP1) ,partial - CSB-YP748722HU CSB-EP748722HU CSB-BP748722HU CSB-MP748722HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CYFIP1, Peptide - MBS426715 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

CYFIP1 Recombinant Protein Antigen - NBP2-49545PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

CYFIP1 Peptide, Human - M34GP03928H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cytoplasmic FMR1-interacting protein 1 (CYFIP1), partial, Recombinant Protein - MBS1482942 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CYFIP1 fusion protein - Ag27419 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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