TERF2IP

Gene Symbol TERF2IP
Entrez Gene 54386
Alt Symbol DRIP5, RAP1
Species Human
Gene Type protein-coding
Description telomeric repeat binding factor 2, interacting protein
Other Description RAP1 homolog|TERF2-interacting telomeric protein 1|TRF2-interacting telomeric RAP1 protein|TRF2-interacting telomeric protein 1|dopamine receptor interacting protein 5|dopamine receptor-interacting protein 5|hRap1|repressor/activator protein 1 homolog|telomeric repeat-binding factor 2-interacting protein 1
Swissprots Q9NWR2 Q9NYB0 B4DQN4 Q8WYZ3 Q4W4Y2
Accessions EAW95616 EAW95617 EAW95618 Q9NYB0 AA769291 AF250393 AAQ14259 AF262988 AAF72711 AF289599 AAL55783 AK000669 BAA91317 AK298880 BAG60996 AK307901 BC004465 AAH04465 BC005841 AAH05841 BC016739 BC022428 AAH22428 BC078171 AAH78171 HQ448265 ADQ32745 XR_933334 NM_018975 NP_061848
Function Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous. Highly expressed.

TERF2IP (D9H4) Rabbit mAb - 5433 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9H4
Western blot analysis of extracts from various cell lines using TERF2IP (D9H4) Rabbit mAb.

RAP1 (5G7) - sc-47695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAP1 (5G7): sc-47695. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear staining of lymphoid cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.

RAP1 (4C8/1) - sc-53434 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAP1 (4C8/1): sc-53434. Western blot analysis of RAP1 expression in HeLa (A), HL-60 (B), C32 (C), A-431 (D), NIH/3T3 (E) and K-562 (F) nuclear extracts.

RAP1 (N-20) - sc-13652 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RAP1 (N-20): sc-13652. Western blot analysis of RAP1 expression in non-transfected: sc-117752 (A) and mouse RAP1 transfected: sc-122972 (B) 293T whole cell lysates.

RAP1 (H-300) - sc-28197 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RAP1 (H-300): sc-28197. Western blot analysis of RAP1 expression in HeLa (A), HL-60 (B), IMR-32 (C), C32 (D) and A-431 (E) nuclear extracts and HT-1080 whole cell lysate (F).

RAP1 (V-16) - sc-13653 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RAP1 (V-16): sc-13653. Western blot analysis of RAP1 expression in non-transfected: sc-117752 (A) and mouse RAP1 transfected: sc-122972 (B) 293T whole cell lysates.

Anti-RAP1 antibody - ab111191 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-RAP1 antibody - ab92836 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAP1 antibody - ab125528 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RAP1 antibody (ab125528) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-RAP1 antibody - ab87319 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab87319, at 1/250 dilution, staining RAP1 in formalin-fixed, paraffin-embedded section of Human breast carcinoma tissue by Immunohistochemistry using DAB staining.

Anti-RAP1 antibody [4c8/1] - ab14404 from Abcam

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4c8/1
ab14404 staining RAP1 in the 184A1 epithelial cell line from Human mammary glands by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with methanol/acetone (1:1), permeabilized with 1% Triton X-100 in PBS and blocked with 1% BSA for 10 minutes at 21°C. Samples were incubated with primary antibody (1/50 in PBS + 1% BSA) for 1 hour at 21°C. An undiluted Alexa Fluor®488-conjugated Donkey anti-mouse IgG polyclonal was used as the secondary antibody.See Abreview

Anti-RAP1 antibody [4C8/1] - ab187796 from Abcam

Prices $372.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 4C8/1

Anti-RAP1 antibody [78B356] - ab13889 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 78B356
Detection of hRap1 in 293 cells: 2 ug/ml of ab13889 were used; a protein band of approximately 50 kDa is detected.

Anti-TERF2IP / RAP1 Antibody (Lys252) - LS-C177284 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of RAP1 (K252) pAb in extracts from 293 cells.

Anti-TERF2IP / RAP1 Antibody (aa142-191) IHC-plus™ - LS-B5895 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TERF2IP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5895 concentration 5 ug/ml.

Anti-TERF2IP / RAP1 Antibody IHC-plus™ - LS-B11292 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TERF2IP / RAP1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11292 concentration 5 ug/ml.

Anti-TERF2IP / RAP1 Antibody (aa212-235) - LS-C38742 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TERF2IP / RAP1 Antibody (aa212-235) - LS-C93650 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TERF2IP / RAP1 Antibody (aa212-235) - LS-C93651 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TERF2IP / RAP1 Antibody - LS-C144153 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TERF2IP / RAP1 Antibody (aa212-235) - LS-C710 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of hRap1 in 293 cells: Two microgram of anti-Rap1 was used to detect hRap1 in 293 cells. A protein band with an approximate molecular weight of 50 kD was detected.

Anti-TERF2IP / RAP1 Antibody (aa212-235, clone 78B356.1) - LS-C592 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 78B356.1
Detection of hRap1 in 293 cells: Two micrograms/ml of antibody was used to detect hRap1 in 293 cells. A protein band of approximate molecular weight of 50 kD is detected.

Anti-TERF2IP / RAP1 Antibody (C-Terminus, clone 11C1080) - LS-C184136 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 11C1080

Anti-TERF2IP / RAP1 Antibody (aa349-378, AP) - LS-C207749 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TERF2IP / RAP1 Antibody (aa349-378, APC) - LS-C207751 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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