TERF2IP

Gene Symbol TERF2IP
Entrez Gene 54386
Alt Symbol DRIP5, RAP1
Species Human
Gene Type protein-coding
Description telomeric repeat binding factor 2, interacting protein
Other Description RAP1 homolog|TERF2-interacting telomeric protein 1|TRF2-interacting telomeric RAP1 protein|TRF2-interacting telomeric protein 1|dopamine receptor interacting protein 5|dopamine receptor-interacting protein 5|hRap1|repressor/activator protein 1 homolog|telomeric repeat-binding factor 2-interacting protein 1
Swissprots Q9NWR2 Q9NYB0 B4DQN4 Q8WYZ3 Q4W4Y2
Accessions EAW95616 EAW95617 EAW95618 Q9NYB0 AA769291 AF250393 AAQ14259 AF262988 AAF72711 AF289599 AAL55783 AK000669 BAA91317 AK298880 BAG60996 AK307901 BC004465 AAH04465 BC005841 AAH05841 BC016739 BC022428 AAH22428 BC078171 AAH78171 HQ448265 ADQ32745 XR_933334 NM_018975 NP_061848
Function Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous. Highly expressed.

RAP1 CRISPR/Cas9 KO Plasmid (h) - sc-401709 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 HDR Plasmid (h) - sc-401709-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 Double Nickase Plasmid (h) - sc-401709-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 Double Nickase Plasmid (h2) - sc-401709-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 CRISPR Activation Plasmid (h) - sc-401709-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 CRISPR Activation Plasmid (h2) - sc-401709-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 Lentiviral Activation Particles (h) - sc-401709-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 Lentiviral Activation Particles (h2) - sc-401709-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 siRNA (h) - sc-38554 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAP1 shRNA Plasmid (h) - sc-38554-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAP1 shRNA (h) Lentiviral Particles - sc-38554-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TERF2IP RNAi - H00054386-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU041401 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21220 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21220 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07183 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07183

TERF2IP siRNA (Human) - CRJ0046 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TERF2IP - MBS829086 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAP1 CRISPR/Cas9 KO Plasmid (h2) - sc-401709-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAP1 HDR Plasmid (h2) - sc-401709-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human TERF2IP (NM_018975.3) - SHH425732 from Creative biogene

Category siRNA
Species Reactivities Human

Human TERF2IP siRNA - orb270547 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TERF2IP shRNA Plasmid (Human) - CHJ0046 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TERF2IP miRNA 3'UTR clone - MiUTR3H-07333 from Creative biogene

Species Reactivities Human
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