TERF2IP

Gene Symbol	TERF2IP
Entrez Gene	54386
Alt Symbol	DRIP5, RAP1
Species	Human
Gene Type	protein-coding
Description	telomeric repeat binding factor 2, interacting protein
Other Description	RAP1 homolog|TERF2-interacting telomeric protein 1|TRF2-interacting telomeric RAP1 protein|TRF2-interacting telomeric protein 1|dopamine receptor interacting protein 5|dopamine receptor-interacting protein 5|hRap1|repressor/activator protein 1 homolog|telomeric repeat-binding factor 2-interacting protein 1
Swissprots	Q9NWR2 Q9NYB0 B4DQN4 Q8WYZ3 Q4W4Y2
Accessions	EAW95616 EAW95617 EAW95618 Q9NYB0 AA769291 AF250393 AAQ14259 AF262988 AAF72711 AF289599 AAL55783 AK000669 BAA91317 AK298880 BAG60996 AK307901 BC004465 AAH04465 BC005841 AAH05841 BC016739 BC022428 AAH22428 BC078171 AAH78171 HQ448265 ADQ32745 XR_933334 NM_018975 NP_061848
Function	Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitous. Highly expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAP1 full length protein - ab162732 from Abcam Category Protein Source Wheat germ Species Human

TERF2IP / RAP1 Antibody Blocking Peptide - LS-E2922 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERF2IP / RAP1 Antibody Blocking Peptide - LS-E20916 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERF2IP / RAP1 Antibody Blocking Peptide - LS-E20915 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TERF2IP Protein - H00054386-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TERF2IP-Antibody-C-term-Blocking-peptide - BP14047b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TERF2IP Blocking Peptide - 33R-2322 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAP1 Peptide - AC21-1892-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TERF2IP / RAP1 - H00054386-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TERF2IP / RAP1 - H00054386-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TERF2IP Peptide - 42-483P from ProSci Category Peptide Species Human

TERF2IP fusion protein - Ag6316 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TERF2IP fusion protein - Ag6130 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human TERF2IP, His-tagged - TERF2IP-3181H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) - RPK110Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg - 14-455 from EMD Millipore Prices $452.00 Sizes 650 µg Source expressed in E. coli

RAP1A Blocking Peptide - CBP2691 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

RAP1 (K252) Peptide - BS2934P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1(TERF2I - CSB-YP878922HU CSB-EP878922HU CSB-BP878922HU CSB-MP878922HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TERF2IP Protein - abx164504 from Abbexa Category Protein Species Human, Mouse, Rat

Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP), Recombinant Protein - MBS1300166 from MyBioSource Category Protein Prices $1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,875.00, $1,875.00, $2,340.00, $2,340.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RAP1/TERF2IP, Peptide - MBS427255 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine, Dog

TERF2IP Recombinant Protein Antigen - NBP1-82433PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TERF2IP Peptide, Human - M34GP15797H from Creative Peptides Category Peptide Source Synthetic. Species Human

TERF2IP peptide - orb218554 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

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