Gene Symbol | TAS2R3 |
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Entrez Gene | 50831 |
Alt Symbol | T2R3 |
Species | Human |
Gene Type | protein-coding |
Description | taste receptor, type 2, member 3 |
Other Description | candidate taste receptor T2R3|taste receptor type 2 member 3 |
Swissprots | Q645W2 Q75MV6 Q9NYW6 A4D1U2 |
Accessions | AAF43903 AAS02038 AAU21157 BAD97907 BAD97908 BAD97909 CAI53519 CAK32490 EAL24017 EAW83982 Q9NYW6 BC069337 AAH69337 BC095523 AAH95523 NM_016943 NP_058639 |
Function | Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. {ECO:0000269|PubMed:10761934, ECO:0000269|PubMed:10761935}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells. {ECO:0000269|PubMed:10761934}. |
Top Pathways | Taste transduction |
T2R3 CRISPR/Cas9 KO Plasmid (h) - sc-409917 from Santa Cruz Biotechnology
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T2R3 HDR Plasmid (h) - sc-409917-HDR from Santa Cruz Biotechnology
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T2R3 Double Nickase Plasmid (h) - sc-409917-NIC from Santa Cruz Biotechnology
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T2R3 Double Nickase Plasmid (h2) - sc-409917-NIC-2 from Santa Cruz Biotechnology
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T2R3 CRISPR Activation Plasmid (h) - sc-409917-ACT from Santa Cruz Biotechnology
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T2R3 CRISPR Activation Plasmid (h2) - sc-409917-ACT-2 from Santa Cruz Biotechnology
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T2R3 Lentiviral Activation Particles (h) - sc-409917-LAC from Santa Cruz Biotechnology
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T2R3 Lentiviral Activation Particles (h2) - sc-409917-LAC-2 from Santa Cruz Biotechnology
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T2R3 siRNA (h) - sc-89478 from Santa Cruz Biotechnology
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T2R3 shRNA Plasmid (h) - sc-89478-SH from Santa Cruz Biotechnology
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T2R3 shRNA (h) Lentiviral Particles - sc-89478-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21019 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21019 from Sigma-Aldrich
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TAS2R3 siRNA (Human) - CRH9412 from Cohesion Biosciences
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TAS2R3 RNAi - H00050831-R02 from Novus Biologicals
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TAS2R3 - MBS8211231 from MyBioSource
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shRNA set against Human TAS2R3 (NM_016943.2) - SHH423512 from Creative biogene
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Human TAS2R3 siRNA - orb269914 from Biorbyt
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TAS2R3 shRNA Plasmid (Human) - CHH9412 from Cohesion Biosciences
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TAS2R3 miRNA 3'UTR clone - MiUTR1H-10195 from Creative biogene
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