URI1

Gene Symbol URI1
Entrez Gene 8725
Alt Symbol C19orf2, NNX3, PPP1R19, RMP, URI
Species Human
Gene Type protein-coding
Description URI1, prefoldin-like chaperone
Other Description RNA polymerase II subunit 5-mediating protein|RPB5-mediating protein|protein phosphatase 1 regulatory subunit 19|protein phosphatase 1, regulatory subunit 19|unconventional prefoldin RPB5 interactor 1
Swissprots A8K805 Q9UNU3 Q8TC23 H7BY42 O94763
Accessions O94763 AA678820 AF091095 AAD08679 AK001437 BAG50914 AK226173 AK292170 BAF84859 AK314313 AW003989 AW954529 BC014933 AAH14933 BC026184 AAH26184 BC067259 AAH67259 BG742069 DB461036 HQ234306 XM_005259362 XP_005259419 XM_005259363 XP_005259420 XM_011527435 XP_011525737 NM_001252641 NP_001239570 NM_003796 NP_003787 NR_045557 NM_134447
Function Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
Subcellular Location Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
Tissue Specificity Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. {ECO:0000269|PubMed:21397856, ECO:0000269|PubMed:21730289, ECO:0000269|PubMed:9819440, ECO:0000269|PubMed:9878255}.

RMP Antibody - 5844 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using RMP Antibody.

RMP (D-2) - sc-376011 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RMP (D-2): sc-376011. Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing cytoplasmic and nuclear staining of ovarian stroma cells.

RMP (H-240) - sc-292384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

RMP (K-17) - sc-103869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-C19orf2 antibody - ab72134 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-C19orf2 antibody (ab72134) at 0.04 µg/mlLane 1 : Whole cell lysate from Hela cells at 50 µgLane 2 : Whole cell lysate from Hela cells at 15 µgLane 3 : Whole cell lysate from Hela cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µg

Anti-C19orf2 antibody - ab138069 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-C19orf2 antibody (ab138069) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-C19orf2 antibody - ab67603 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-C19orf2 antibody (ab67603) at 1/500 dilutionLane 1 : C19orf2 transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate Lysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilutionObserved band size : 37 kDa (why is the actual band size different from the predicted?)

Anti-C19orf2 antibody [SP215] - C-terminal - ab183310 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone SP215
Immunohistochemical analysis of Human ovarian adenocarcinoma tissue labeling C19orf2 using ab183310 at a 1/100 dilution.

Anti-C19orf2 antibody - Carboxyterminal end - ab71591 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-C19orf2 antibody - Carboxyterminal end (ab71591) at 1/250 dilutionLane 1 : T47D cell lysateLane 2 : Jurkat cell lysateLysates/proteins at 12.5 µg per lane.

Anti-URI1 / NNX3 Antibody (C-Terminus) - LS-C144147 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (C-Terminus, AP) - LS-C220585 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (aa122-171) - LS-C200606 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from K562 cells using RMP antibody.

Anti-URI1 / NNX3 Antibody (C-Terminus, APC) - LS-C220587 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (C-Terminus, Biotin) - LS-C220588 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (aa359-408) - LS-C111293 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
C19orf2 / NNX3 antibody LS-C111293 Western blot of Fetal Muscle lysate.

Anti-URI1 / NNX3 Antibody (C-Terminus, Azide-free, HRP) - LS-C220589 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (C-Terminus, FITC) - LS-C220590 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (C-Terminus, PE) - LS-C220591 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (aa458-508) - LS-C287985 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (aa415-464) - LS-C291381 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody - LS-C306622 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (aa350-400) - LS-C287984 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (aa181-226) - LS-C313935 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-URI1 / NNX3 Antibody (aa347-376) - LS-C97594 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-RMP antibody is used in Western blot to detect RMP in T47D (left) and Jurkat (right) cell line lysates.

Anti-URI1 / NNX3 Antibody (C-Terminus) - LS-C330637 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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