| Gene Symbol |
URI1
|
| Entrez Gene |
8725
|
| Alt Symbol |
C19orf2, NNX3, PPP1R19, RMP, URI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
URI1, prefoldin-like chaperone
|
| Other Description |
RNA polymerase II subunit 5-mediating protein|RPB5-mediating protein|protein phosphatase 1 regulatory subunit 19|protein phosphatase 1, regulatory subunit 19|unconventional prefoldin RPB5 interactor 1
|
| Swissprots |
A8K805 Q9UNU3 Q8TC23 H7BY42 O94763
|
| Accessions |
O94763 AA678820 AF091095 AAD08679 AK001437 BAG50914 AK226173 AK292170 BAF84859 AK314313 AW003989 AW954529 BC014933 AAH14933 BC026184 AAH26184 BC067259 AAH67259 BG742069 DB461036 HQ234306 XM_005259362 XP_005259419 XM_005259363 XP_005259420 XM_011527435 XP_011525737 NM_001252641 NP_001239570 NM_003796 NP_003787 NR_045557 NM_134447
|
| Function |
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
|
| Subcellular Location |
Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
|
| Tissue Specificity |
Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. {ECO:0000269|PubMed:21397856, ECO:0000269|PubMed:21730289, ECO:0000269|PubMed:9819440, ECO:0000269|PubMed:9878255}.
|