GLS

Gene Symbol	GLS
Entrez Gene	2744
Alt Symbol	AAD20, GAC, GAM, GLS1, KGA
Species	Human
Gene Type	protein-coding
Description	glutaminase
Other Description	K-glutaminase|L-glutamine amidohydrolase|glutaminase C|glutaminase kidney isoform, mitochondrial|glutaminase, phosphate-activated
Swissprots	Q9UL07 Q9UL05 Q9UL06 O94925 Q9UN40
Accessions	AAY14767 AAY24182 AAY24320 EAX10856 EAX10857 EAX10858 EAX10859 EAX10860 O94925 AB020645 BAA74861 AF097492 AAF00088 AF097493 AAF00089 AF097494 AF097495 AAF00090 AF158555 AAD47056 AF223943 AAF33825 AF279697 AAG17700 AF327434 AAG47842 AJ431620 AK001220 BAG50870 AK092974 AK123493 AK289747 BAF82436 AK294927 BAH11927 AK298266 BAH12745 BC038507 AAH38507 BM148085 BX641148 CR749593 CAH18392 Y08264 XM_005246467 XP_005246524 XM_006712435 XP_006712498 XR_241306 XR_922905 NM_001256310 NP_001243239 NM_014905 NP_055720
Function	Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
Subcellular Location	Isoform 1: Cytoplasm, cytosol.
Tissue Specificity	Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. {ECO:0000269|PubMed:11015561}.
Top Pathways	Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse GLS / Glutaminase ELISA Kit (Sandwich ELISA) - LS-F6990 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Human GLS / Glutaminase ELISA Kit (Sandwich ELISA) - LS-F8038 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.113 ng/ml Range 0.313-20 ng/ml

Rat GLS / Glutaminase ELISA Kit (Sandwich ELISA) - LS-F9608 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Human GLS / Glutaminase ELISA Kit (Sandwich ELISA) - LS-F11550 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Human Glutaminase ELISA Kit - abx151681 from Abbexa Category ELISA Kit Sensitivity 0.119 ng/ml Range 0.313 ng/ml - 20 ng/ml

Glutaminase (GLS), Human, ELISA Kit - SEJ026Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.117ng/mL Range 0.312-20ng/mL

glutaminase, ELISA Kit - MBS2602981 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.05ng/ml. Range 10 ng/ml-0.156ng/ml

Glutaminase (GLS), ELISA Kit - MBS2020465 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.113ng/mL. Range 0.313-20ng/mL

ELISA Kit for Glutaminase (GLS) - SEJ026Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.113ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Glutaminase (GLS) - SEJ026Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Glutaminase (GLS) - SEJ026Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.135ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Glutaminase (GLS) - SEJ026Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.113ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse GLS / Glutaminase ELISA Kit (Custom ELISA) - LS-F17740 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Rat GLS / Glutaminase ELISA Kit (Custom ELISA) - LS-F17741 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human Glutaminase (GLS) ELISA Kit - EKU04461 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.113 ng/mL Range 0.312-20 ng/mL

Human Glutaminase kidney isoform, mitochondrial ELISA Kit - abx251046 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Human Glutaminase kidney isoform, mitochondrial ELISA Kit - EKE55145 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.098 ng/ml Range 0.312-20 ng/mL

GLS ELISA Kit (Human) : 96 Wells (OKEH02473) - OKEH02473 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.098 ng/mL Range 0.312 - 20 ng/mL

Human Glutaminase kidney isoform, mitochondrial ELISA Kit - EK3615 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.098ng/ml Range 0.312-20 ng/mL

Glutaminase Microplate Assay Kit - orb390771 from Biorbyt Category Assay Kit Prices $510.00 Sizes 100 assays

anti-Glutaminase antibody - ARG55696 from Arigo Biolaboratories Category ELISA Kit

Glutaminase kidney isoform mitochondrial (GLS), ELISA Kit - MBS2610421 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutaminase (GLS), ELISA Kit - MBS451898 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.117ng/mL Range 0.312-20ng/mL

Glutaminase kidney isoform, ELISA Kit - MBS2884802 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Glutaminase kidney isoform, ELISA Kit - MBS9427449 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.098ng/mL Range 0.312-20 ng/mL

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