GLS

Gene Symbol GLS
Entrez Gene 2744
Alt Symbol AAD20, GAC, GAM, GLS1, KGA
Species Human
Gene Type protein-coding
Description glutaminase
Other Description K-glutaminase|L-glutamine amidohydrolase|glutaminase C|glutaminase kidney isoform, mitochondrial|glutaminase, phosphate-activated
Swissprots Q9UL07 Q9UL05 Q9UL06 O94925 Q9UN40
Accessions AAY14767 AAY24182 AAY24320 EAX10856 EAX10857 EAX10858 EAX10859 EAX10860 O94925 AB020645 BAA74861 AF097492 AAF00088 AF097493 AAF00089 AF097494 AF097495 AAF00090 AF158555 AAD47056 AF223943 AAF33825 AF279697 AAG17700 AF327434 AAG47842 AJ431620 AK001220 BAG50870 AK092974 AK123493 AK289747 BAF82436 AK294927 BAH11927 AK298266 BAH12745 BC038507 AAH38507 BM148085 BX641148 CR749593 CAH18392 Y08264 XM_005246467 XP_005246524 XM_006712435 XP_006712498 XR_241306 XR_922905 NM_001256310 NP_001243239 NM_014905 NP_055720
Function Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
Subcellular Location Isoform 1: Cytoplasm, cytosol.
Tissue Specificity Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. {ECO:0000269|PubMed:11015561}.
Top Pathways Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation

Active human Glutaminase full length protein - ab198065 from Abcam

Category Protein
Prices $1,220.00
Sizes 20 µg
Source E. coli
Species Human
Example of specific activity of ab198065

Human Glutaminase protein fragment - ab152430 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152430 stained with Coomassie Blue.

GLS-Antibody-C-term-Blocking-Peptide - BP8809b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Human GLS protein - orb245849 from Biorbyt

Category Protein
Prices $340.00, $629.00, $1,003.00, $1,556.00
Sizes 50 μg, 200 μg, 500 μg, 1 mg
Species Human

Glutaminase kidney isoform - H00002744-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Glutaminase kidney isoform - H00002744-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

GLS fusion protein - ag20354 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

GLS fusion protein - Ag3505 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

GLS fusion protein - Ag14002 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Glutaminase (GLS) - RPJ026Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Glutaminase (GLS) - RPJ026Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Glutaminase (GLS) - RPJ026Mu02 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Glutaminase (GLS) - RPJ026Ra01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Rat

Glutaminase - PPT-53500 from Nordic BioSite

Category Protein

Recombinant Glutaminase (GLS) - RPJ026Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant Human Glutaminase kidney isoform, mitochondrial(GLS) - CSB-EP009528HU CSB-BP009528HU CSB-MP009528HU from Cusabio

Category Protein
Source E.coli or Baculovirus or Mammalian cell
Species Human

Recombinant Glutaminase(glsA) - CSB-YP009528CQG CSB-EP009528CQG CSB-BP009528CQG CSB-MP009528CQG from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Corynebacterium

Recombinant Glutaminase(glsA) - CSB-YP009528VFI CSB-EP009528VFI CSB-BP009528VFI CSB-MP009528VFI from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Vibrio

Recombinant Glutaminase(glsA) - CSB-YP009528CMN CSB-EP009528CMN CSB-BP009528CMN CSB-MP009528CMN from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Clostridium

Recombinant Glutaminase(glsA) - CSB-YP009528VFE CSB-EP009528VFE CSB-BP009528VFE CSB-MP009528VFE from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Vibrio

Recombinant Glutaminase(glsA) - CSB-YP009528SNN CSB-EP009528SNN CSB-BP009528SNN CSB-MP009528SNN from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Streptomyces

Recombinant Human Glutaminase kidney isoform, mitochondrial(GLS) - CSB-YP009528HU from Cusabio

Category Protein
Source Yeast
Species Human

Glutaminase Protein (Recombinant) - abx166465 from Abbexa

Category Protein
Source Human
Species Human

Glutaminase kidney isoform - TP306265 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Glutaminase kidney isoform
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