| Gene Symbol |
SIN3A
|
| Entrez Gene |
25942
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SIN3 transcription regulator family member A
|
| Other Description |
SIN3 homolog A, transcription regulator|SIN3 transcription regulator homolog A|histone deacetylase complex subunit Sin3a|paired amphipathic helix protein Sin3a|transcriptional co-repressor Sin3A|transcriptional corepressor Sin3a|transcriptional regulator, SIN3A
|
| Swissprots |
Q8N8N4 Q96ST3 Q8WV18 Q8NC83 Q9UFQ1 Q96L98 B2RNS5
|
| Accessions |
EAW99249 EAW99250 EAW99251 Q96ST3 AF418569 AAP97288 AK027559 BAB55197 AK074800 BAG52005 AK074903 BAC11280 AK096477 BAC04801 AL117513 CAB55972 AL832463 AY044430 AAK95854 BC018973 AAH18973 BC030563 BC041047 BC052275 BC066364 BC137098 AAI37099 BC137099 AAI37100 BM676304 BX649162 DB074084 XM_006720465 XP_006720528 XM_006720466 XP_006720529 XM_006720467 XP_006720530 NM_001145357 NP_001138829 NM_001145358 NP_001138830 NM_015477 NP_056292
|
| Function |
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. {ECO:0000269|PubMed:12150998}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00810, ECO:0000269|PubMed:16820529}. Nucleus, nucleolus {ECO:0000269|PubMed:16820529}. Note=Recruited to the nucleolus by SAP30L.
|
| Top Pathways |
Huntington's disease, Transcriptional misregulation in cancer
|