SIN3A

Gene Symbol SIN3A
Entrez Gene 25942
Alt Symbol -
Species Human
Gene Type protein-coding
Description SIN3 transcription regulator family member A
Other Description SIN3 homolog A, transcription regulator|SIN3 transcription regulator homolog A|histone deacetylase complex subunit Sin3a|paired amphipathic helix protein Sin3a|transcriptional co-repressor Sin3A|transcriptional corepressor Sin3a|transcriptional regulator, SIN3A
Swissprots Q8N8N4 Q96ST3 Q8WV18 Q8NC83 Q9UFQ1 Q96L98 B2RNS5
Accessions EAW99249 EAW99250 EAW99251 Q96ST3 AF418569 AAP97288 AK027559 BAB55197 AK074800 BAG52005 AK074903 BAC11280 AK096477 BAC04801 AL117513 CAB55972 AL832463 AY044430 AAK95854 BC018973 AAH18973 BC030563 BC041047 BC052275 BC066364 BC137098 AAI37099 BC137099 AAI37100 BM676304 BX649162 DB074084 XM_006720465 XP_006720528 XM_006720466 XP_006720529 XM_006720467 XP_006720530 NM_001145357 NP_001138829 NM_001145358 NP_001138830 NM_015477 NP_056292
Function Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. {ECO:0000269|PubMed:12150998}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00810, ECO:0000269|PubMed:16820529}. Nucleus, nucleolus {ECO:0000269|PubMed:16820529}. Note=Recruited to the nucleolus by SAP30L.
Top Pathways Huntington's disease, Transcriptional misregulation in cancer

SIN3A (D1B7) Rabbit mAb - 7691 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1B7
Western blot analysis of extracts from various cell lines using SIN3A (D1B7) Rabbit mAb.

SIN3A (D9D6) Rabbit mAb - 8056 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9D6
Western blot analysis of extracts from various cell lines using SIN3A (D9D6) Rabbit mAb.

mSin3A (AK-11) - sc-767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
mSin3A (AK-11): sc-767. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear staining.

mSin3A (G-11) - sc-5299 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
mSin3A (G-11): sc-5299. Western blot analysis of mSin3A expression in HeLa (A) and K-562 (B) whole cell lysates.

mSin3A (K-20) - sc-994 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
mSin3A (K-20): sc-994. Western blot analysis of mSin3A expression in HeLa (A), Jurkat (B) and K-562 (C) whole cell lysates.

Anti-mSin3A antibody - ab70727 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-mSin3A antibody (ab70727) at 0.04 µg/mlLane 1 : Whole cell lysate from HeLa cells at 50 µgLane 2 : Whole cell lysate from HeLa cells at 15 µgLane 3 : Whole cell lysate from HeLa cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µgLane 5 : Whole cell lysate from mouse NIH3T3 cells at 50 µgdeveloped using the ECL technique

Anti-mSin3A antibody - ab184128 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of 4% paraformaldehyde-fixed HeLa cells labeling mSin3A with ab184128 at 1/1000 dilution (green). Blue: Hoechst 33342 staining.

Anti-mSin3A antibody - ab83292 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-mSin3A antibody (ab83292) at 1 µg/ml + HeLa cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-mSin3A antibody - ab84380 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma tissue using 1/250 ab84380. Detection: DAB staining.

Anti-mSin3A antibody [EPR6779] - ab137090 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6779
All lanes : Anti-mSin3A antibody [EPR6779] (ab137090) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-mSin3A antibody [EPR6780] - ab129087 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6780
All lanes : Anti-mSin3A antibody [EPR6780] (ab129087) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLane 3 : 293T cell lysateLane 4 : PC12 cell lysateLane 5 : RAW 264.7 cell lysateLane 6 : Mouse lung lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-mSin3A antibody - C-terminal - ab174909 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-mSin3A antibody - C-terminal (ab174909) at 1/100 dilution + NIH3T3 cell lysate at 35 µg

Anti-mSin3A antibody - ChIP Grade - ab3479 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-mSin3A antibody - N-terminal - ab180626 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab180626. Blue DAPI for nuclear staining.

Anti-SIN3A Antibody IHC-plus™ - LS-B10248 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SIN3A Antibody (N-Terminus) IHC-plus™ - LS-B3492 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIN3A antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3492 concentration 5 ug/ml.

Anti-SIN3A Antibody (aa1-19) - LS-C39099 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (aa2-18) - LS-C10160 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (aa1-50) - LS-C91390 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (aa375-425) - LS-C91391 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (C-Terminus) - LS-C91392 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (aa1078-1106, AP) - LS-C269448 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (aa1078-1106, Biotin) - LS-C269450 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (aa1078-1106, APC) - LS-C269449 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIN3A Antibody (aa1078-1106, FITC) - LS-C269451 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more