SIN3A

Gene Symbol	SIN3A
Entrez Gene	25942
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SIN3 transcription regulator family member A
Other Description	SIN3 homolog A, transcription regulator|SIN3 transcription regulator homolog A|histone deacetylase complex subunit Sin3a|paired amphipathic helix protein Sin3a|transcriptional co-repressor Sin3A|transcriptional corepressor Sin3a|transcriptional regulator, SIN3A
Swissprots	Q8N8N4 Q96ST3 Q8WV18 Q8NC83 Q9UFQ1 Q96L98 B2RNS5
Accessions	EAW99249 EAW99250 EAW99251 Q96ST3 AF418569 AAP97288 AK027559 BAB55197 AK074800 BAG52005 AK074903 BAC11280 AK096477 BAC04801 AL117513 CAB55972 AL832463 AY044430 AAK95854 BC018973 AAH18973 BC030563 BC041047 BC052275 BC066364 BC137098 AAI37099 BC137099 AAI37100 BM676304 BX649162 DB074084 XM_006720465 XP_006720528 XM_006720466 XP_006720529 XM_006720467 XP_006720530 NM_001145357 NP_001138829 NM_001145358 NP_001138830 NM_015477 NP_056292
Function	Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. {ECO:0000269|PubMed:12150998}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00810, ECO:0000269|PubMed:16820529}. Nucleus, nucleolus {ECO:0000269|PubMed:16820529}. Note=Recruited to the nucleolus by SAP30L.
Top Pathways	Huntington's disease, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human mSin3A full length protein - ab153255 from Abcam Category Protein Source Wheat germ Species Human

Human mSin3A protein fragment - ab153256 from Abcam Category Protein Source Wheat germ Species Human

mSin3A peptide - ab4995 from Abcam Category Peptide

SIN3A Antibody Blocking Peptide - LS-E6469 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIN3A Antibody Blocking Peptide - LS-E11389 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SIN3A Protein - H00025942-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

SIN3A Partial Recombinant Protein - H00025942-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SIN3A Blocking Peptide - 33R-4635 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIN3A - H00025942-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SIN3A - H00025942-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SIN3A - H00025942-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

SIN3A - H00025942-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SIN3A - H00025942-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SIN3A fusion protein - ag6219 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SIN3A, GST-tagged - SIN3A-2676H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Paired amphipathic helix protein Sin3a(SIN3A) ,partial - CSB-YP836303HU CSB-EP836303HU CSB-BP836303HU CSB-MP836303HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Paired amphipathic helix protein Sin3a (SIN3A), partial, Recombinant Protein - MBS1412659 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SIN3A Recombinant Protein Antigen - NBP2-38564PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SIN3A Protein - NBP2-38949PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Sin3A-Antibody-Center-Blocking-Peptide - BP1907c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Sin3A-Antibody-C-term-Blocking-Peptide - BP1907b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIN3A-Antibody-N-term-Blocking-Peptide - BP1907a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIN3A Peptide, Human - M34GP14257H from Creative Peptides Category Peptide Source Synthetic. Species Human

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