| Gene Symbol |
CUL3
|
| Entrez Gene |
8452
|
| Alt Symbol |
CUL-3, PHA2E
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cullin 3
|
| Other Description |
cullin-3
|
| Swissprots |
B8ZZC3 Q9UBI8 O75415 A8K536 Q13618 Q9UET7 Q569L3
|
| Accessions |
AAX93287 AAY24157 EAW70828 EAW70829 EAW70830 Q13618 AB014517 BAA31592 AF052147 AAC28621 AF062537 AAC36682 AF064087 AAC36304 AK098531 AK291151 BAF83840 AK299644 BAH13086 AK308496 AY007151 AY337761 AAQ01660 BC031844 AAH31844 BC039598 AAH39598 BC092409 AAH92409 BQ688156 U58089 AAC50546 XM_006712800 XP_006712863 XM_011511994 XP_011510296 XM_011511995 XP_011510297 XM_011511996 XP_011510298 XM_011511997 XP_011510299 NM_001257197 NP_001244126 NM_001257198 NP_001244127 NM_003590 NP_003581
|
| Function |
Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have
|
| Subcellular Location |
Nucleus. Golgi apparatus.
|
| Tissue Specificity |
Widely expressed.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|