CUL3

Gene Symbol	CUL3
Entrez Gene	8452
Alt Symbol	CUL-3, PHA2E
Species	Human
Gene Type	protein-coding
Description	cullin 3
Other Description	cullin-3
Swissprots	B8ZZC3 Q9UBI8 O75415 A8K536 Q13618 Q9UET7 Q569L3
Accessions	AAX93287 AAY24157 EAW70828 EAW70829 EAW70830 Q13618 AB014517 BAA31592 AF052147 AAC28621 AF062537 AAC36682 AF064087 AAC36304 AK098531 AK291151 BAF83840 AK299644 BAH13086 AK308496 AY007151 AY337761 AAQ01660 BC031844 AAH31844 BC039598 AAH39598 BC092409 AAH92409 BQ688156 U58089 AAC50546 XM_006712800 XP_006712863 XM_011511994 XP_011510296 XM_011511995 XP_011510297 XM_011511996 XP_011510298 XM_011511997 XP_011510299 NM_001257197 NP_001244126 NM_001257198 NP_001244127 NM_003590 NP_003581
Function	Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have
Subcellular Location	Nucleus. Golgi apparatus.
Tissue Specificity	Widely expressed.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cullin 3 full length protein - ab152871 from Abcam Category Protein Source Wheat germ Species Human

Human Cullin 3 protein fragment - ab152872 from Abcam Category Protein Source Wheat germ Species Human

Cullin 3 / CUL3 Antibody Blocking Peptide - LS-E22403 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cullin 3 Protein - H00008452-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cullin 3 Protein - H00008452-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Cullin 3 Blocking Peptide - abx063471 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

Cullin-3 - H00008452-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Cullin-3 - H00008452-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Cullin-3 - H00008452-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Cullin-3 - H00008452-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cullin-3 - H00008452-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CUL3 fusion protein - ag1555 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CUL3/RBX1 - CUL3-148H from Creative Biomart Category Protein Source Insect cells Species Human

Cullin 3 Blocking Peptide - CBP2277 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

CUL3 Peptide - BS5678P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Cullin-3(CUL3) - CSB-YP621687HU CSB-EP621687HU CSB-BP621687HU CSB-MP621687HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cullin-3 - TP308066 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Cullin 3, Peptide - MBS428542 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

Recombinant Human CUL3 protein, MYC/DDK-tagged - CUL3-321H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human CUL3 protein, GST-tagged - CUL3-322H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human CUL3/RBX1, GST-tagged - CUL3-240H from Creative Biomart Category Protein Source Insect cells Species Human

CUL3-Blocking-Peptide-C-term - BP5425b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CUL3 Peptide, Human - M34GP03840H from Creative Peptides Category Peptide Source Synthetic. Species Human

CUL3 peptide - orb218140 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Cullin-3 (CUL3), Recombinant Protein - MBS1430013 from MyBioSource Category Protein Prices $1,585.00, $1,585.00, $1,810.00, $1,810.00, $2,730.00, $2,730.00, $3,175.00, $3,175.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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