Gene Symbol |
FGFBP1
|
Entrez Gene |
9982
|
Alt Symbol |
FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
fibroblast growth factor binding protein 1
|
Other Description |
17 kDa HBGF-binding protein|17 kDa heparin-binding growth factor-binding protein|FGF-binding protein 1|fibroblast growth factor-binding protein 1|heparin-binding growth factor binding protein
|
Swissprots |
A8K5J2 Q14512
|
Accessions |
AAD39216 EAW92748 Q14512 AK291307 BAF83996 AW959908 BC003628 AAH03628 BC008910 AAH08910 BC018852 BQ435589 BX434467 M60047 AAA58636 NM_005130 NP_005121
|
Function |
Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. {ECO:0000269|PubMed:11509569, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605, ECO:0000269|PubMed:9334727}.
|
Subcellular Location |
Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.
|
Tissue Specificity |
Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo- epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605}.
|