| Gene Symbol | FGFBP1 |
|---|---|
| Entrez Gene | 9982 |
| Alt Symbol | FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibroblast growth factor binding protein 1 |
| Other Description | 17 kDa HBGF-binding protein|17 kDa heparin-binding growth factor-binding protein|FGF-binding protein 1|fibroblast growth factor-binding protein 1|heparin-binding growth factor binding protein |
| Swissprots | A8K5J2 Q14512 |
| Accessions | AAD39216 EAW92748 Q14512 AK291307 BAF83996 AW959908 BC003628 AAH03628 BC008910 AAH08910 BC018852 BQ435589 BX434467 M60047 AAA58636 NM_005130 NP_005121 |
| Function | Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. {ECO:0000269|PubMed:11509569, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605, ECO:0000269|PubMed:9334727}. |
| Subcellular Location | Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. |
| Tissue Specificity | Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo- epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605}. |
FGF-BP CRISPR/Cas9 KO Plasmid (h) - sc-404956 from Santa Cruz Biotechnology
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FGF-BP HDR Plasmid (h) - sc-404956-HDR from Santa Cruz Biotechnology
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FGF-BP Double Nickase Plasmid (h) - sc-404956-NIC from Santa Cruz Biotechnology
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FGF-BP Double Nickase Plasmid (h2) - sc-404956-NIC-2 from Santa Cruz Biotechnology
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FGF-BP CRISPR Activation Plasmid (h) - sc-404956-ACT from Santa Cruz Biotechnology
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FGF-BP CRISPR Activation Plasmid (h2) - sc-404956-ACT-2 from Santa Cruz Biotechnology
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FGF-BP Lentiviral Activation Particles (h) - sc-404956-LAC from Santa Cruz Biotechnology
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FGF-BP Lentiviral Activation Particles (h2) - sc-404956-LAC-2 from Santa Cruz Biotechnology
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FGF-BP siRNA (h) - sc-62314 from Santa Cruz Biotechnology
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FGF-BP shRNA Plasmid (h) - sc-62314-SH from Santa Cruz Biotechnology
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FGF-BP shRNA (h) Lentiviral Particles - sc-62314-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU103141 from Sigma-Aldrich
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MISSION® esiRNA - EHU138501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8667 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8667 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02814 from Sigma-Aldrich
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FGFBP1 siRNA (Human) - CRH6715 from Cohesion Biosciences
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FGF-BP RNAi - H00009982-R01 from Novus Biologicals
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FGFBP1 - MBS8238030 from MyBioSource
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shRNA set against Human FGFBP1 (NM_005130.4) - SHH294625 from Creative biogene
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FGFBP1 shRNA Plasmid (Human) - CHH6715 from Cohesion Biosciences
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FGFBP1 miRNA 3'UTR clone - MiUTR4H-TG11220 from Creative biogene
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