| Gene Symbol |
HIST1H2BM
|
| Entrez Gene |
8342
|
| Alt Symbol |
H2B/e, H2BFE, dJ160A22.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2bm
|
| Other Description |
H2B histone family, member E|histone 1, H2bm|histone H2B type 1-M|histone H2B.e
|
| Swissprots |
Q6NWQ3 Q99879
|
| Accessions |
AAN06696 CAB06033 EAX03110 Q99879 BC066244 AAH66244 BC067485 AAH67485 BC067486 AAH67486 BC067487 AAH67487 BC067488 AAH67488 BC067489 AAH67489 NM_003521 NP_003512
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|