Gene Symbol | MC2R |
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Entrez Gene | 4158 |
Alt Symbol | ACTHR |
Species | Human |
Gene Type | protein-coding |
Description | melanocortin 2 receptor (adrenocorticotropic hormone) |
Other Description | ACTH receptor|MC2 receptor|adrenocorticotropic hormone receptor|adrenocorticotropin receptor|corticotropin receptor |
Swissprots | Q504X6 Q01718 Q3MI45 A8K016 |
Accessions | AAD14989 AAO67714 BAC06130 CAA46587 EAX01503 Q01718 AK289381 BAF82070 AK315319 BAG37722 BC069074 AAH69074 BC094710 AAH94710 BC104169 AAI04170 BC104170 AAI04171 BP196054 Y10259 NM_000529 NP_000520 NM_001291911 NP_001278840 |
Function | Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). {ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Melanocytes and corticoadrenal tissue. |
Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
MC2-R CRISPR/Cas9 KO Plasmid (h) - sc-402854 from Santa Cruz Biotechnology
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MC2-R HDR Plasmid (h) - sc-402854-HDR from Santa Cruz Biotechnology
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MC2-R Double Nickase Plasmid (h) - sc-402854-NIC from Santa Cruz Biotechnology
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MC2-R Double Nickase Plasmid (h2) - sc-402854-NIC-2 from Santa Cruz Biotechnology
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MC2-R CRISPR Activation Plasmid (h) - sc-402854-ACT from Santa Cruz Biotechnology
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MC2-R CRISPR Activation Plasmid (h2) - sc-402854-ACT-2 from Santa Cruz Biotechnology
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MC2-R Lentiviral Activation Particles (h) - sc-402854-LAC from Santa Cruz Biotechnology
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MC2-R Lentiviral Activation Particles (h2) - sc-402854-LAC-2 from Santa Cruz Biotechnology
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MC2-R siRNA (h) - sc-40109 from Santa Cruz Biotechnology
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MC2-R shRNA Plasmid (h) - sc-40109-SH from Santa Cruz Biotechnology
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MC2-R shRNA (h) Lentiviral Particles - sc-40109-V from Santa Cruz Biotechnology
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Melanocortin-2 R/MC2R RNAi - H00004158-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1734 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1734 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11656 from Sigma-Aldrich
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MC2R siRNA (Human) - CRH2830 from Cohesion Biosciences
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shRNA set against Human MC2R (NM_000529.2) - SHH339039 from Creative biogene
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shRNA set against Human MC2R(NM_000529.2) - SHH180299 from Creative biogene
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Human MC2R siRNA - orb263332 from Biorbyt
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MC2R shRNA Plasmid (Human) - CHH2830 from Cohesion Biosciences
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MC2R miRNA 3'UTR clone - MiUTR1H-06150 from Creative biogene
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