| Gene Symbol | ACE |
|---|---|
| Entrez Gene | 1636 |
| Alt Symbol | ACE1, CD143, DCP, DCP1, ICH, MVCD3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | angiotensin I converting enzyme |
| Other Description | CD143 antigen|angiotensin I converting enzyme (peptidyl-dipeptidase A) 1|angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript|angiotensin converting enzyme, somatic isoform|angiotensin-converting enzyme|carboxycathepsin|dipeptidyl carboxypeptidase 1|dipeptidyl carboxypeptidase I|kininase II|peptidase P|testicular ECA |
| Swissprots | E7EU16 B0LPF0 Q59GY8 P22966 Q7M4L4 Q53YX9 P12821 B4DXI3 |
| Accessions | AAD28560 AAD28561 AAP03651 AAP13243 AAR03504 ABA39228 ABA39229 ABY87529 AHV83440 CAA02045 EAW94311 EAW94312 EAW94313 EAW94314 EAW94315 EAW94316 EAW94317 EAW94318 EAW94319 EAW94320 EAW94321 P12821 AB208971 BAD92208 AK296566 BAG59186 AK300516 BAG62228 AK301988 BAG63395 AK302019 BAG63418 AK309514 BM908180 BM908222 J04144 AAA51684 JQ927553 AFK65504 M26657 AAA60611 M29981 S81361 AAD14360 X16295 CAA34362 XM_005257110 XP_005257167 XM_006721737 XP_006721800 NM_000789 NP_000780 NM_001178057 NP_001171528 NM_152830 NP_690043 NM_152831 |
| Function | Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. |
| Subcellular Location | Angiotensin-converting enzyme, soluble form: Secreted. |
| Tissue Specificity | Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15671045}. |
| Top Pathways | Hypertrophic cardiomyopathy (HCM), Chagas disease (American trypanosomiasis), Renin-angiotensin system |