ACE

Gene Symbol ACE
Entrez Gene 1636
Alt Symbol ACE1, CD143, DCP, DCP1, ICH, MVCD3
Species Human
Gene Type protein-coding
Description angiotensin I converting enzyme
Other Description CD143 antigen|angiotensin I converting enzyme (peptidyl-dipeptidase A) 1|angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript|angiotensin converting enzyme, somatic isoform|angiotensin-converting enzyme|carboxycathepsin|dipeptidyl carboxypeptidase 1|dipeptidyl carboxypeptidase I|kininase II|peptidase P|testicular ECA
Swissprots E7EU16 B0LPF0 Q59GY8 P22966 Q7M4L4 Q53YX9 P12821 B4DXI3
Accessions AAD28560 AAD28561 AAP03651 AAP13243 AAR03504 ABA39228 ABA39229 ABY87529 AHV83440 CAA02045 EAW94311 EAW94312 EAW94313 EAW94314 EAW94315 EAW94316 EAW94317 EAW94318 EAW94319 EAW94320 EAW94321 P12821 AB208971 BAD92208 AK296566 BAG59186 AK300516 BAG62228 AK301988 BAG63395 AK302019 BAG63418 AK309514 BM908180 BM908222 J04144 AAA51684 JQ927553 AFK65504 M26657 AAA60611 M29981 S81361 AAD14360 X16295 CAA34362 XM_005257110 XP_005257167 XM_006721737 XP_006721800 NM_000789 NP_000780 NM_001178057 NP_001171528 NM_152830 NP_690043 NM_152831
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Subcellular Location Angiotensin-converting enzyme, soluble form: Secreted.
Tissue Specificity Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15671045}.
Top Pathways Hypertrophic cardiomyopathy (HCM), Chagas disease (American trypanosomiasis), Renin-angiotensin system

ACE (2E2) - sc-23908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACE (2E2): sc-23908. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse kidney tissue showing membrane localization.

ACE (C-20) - sc-12187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACE (C-20): sc-12187. Western blot analysis of ACE expression in mouse kidney tissue extract.

ACE (H-170) - sc-20791 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACE (H-170): sc-20791. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse kidney tissue showing membrane localization.

ACE (B-6) - sc-374198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACE (B-6): sc-374198. Western blot analysis of ACE expression in mouse kidney (A) and human kidney (B) tissue extracts.

ACE (E-9) - sc-271860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACE (E-9): sc-271860. Western blot analysis of ACE expression in mouse kidney tissue extract.

ACE (H-9) - sc-376132 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACE (H-9): sc-376132. Western blot analysis of ACE expression in mouse kidney (A) and human kidney (B) tissue extracts.

ACE (3H533) - sc-69991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACE (3H533): sc-69991. Western blot analysis of ACE expression in mouse kidney tissue extract.

ACE (3H536) - sc-69992 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

ACE (5C5) - sc-23909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of ACE expression in human kidney tissue extract immunoprecipitated with ACE (5C5): sc-23909 and detected with ACE (N-20): sc-12184.

ACE (N-20) - sc-12184 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACE (N-20): sc-12184. Western blot analysis of ACE expression in mouse kidney (A) and human kidney (B) tissue extracts.

ACE (2Q2297) - sc-69993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal

ACE (2Q2296) - sc-69994 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal

Anti-Angiotensin Converting Enzyme 1 antibody - ab28311 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Molecular weight markersLanes 2 - 4 : Anti-Angiotensin Converting Enzyme 1 antibody (ab28311) at 1/1000 dilutionLane 1 : As aboveLane 2 : ACE1 at 0.05 µgLane 3 : ACE1 at 0.01 µgLane 4 : ACE1 at 0.001 µgObserved band size : 150 kDa (why is the actual band size different from the predicted?)

Anti-Angiotensin Converting Enzyme 1 antibody - ab85955 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Angiotensin Converting Enzyme 1 antibody (ab85955) at 1 µg/mlLane 1 : Lung (Human) Tissue LysateLane 2 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Angiotensin Converting Enzyme 1 antibody - ab134709 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue labelling Angiotensin Converting Enzyme 1 with ab134709 at 1/50 dilution.

Anti-Angiotensin Converting Enzyme 1 antibody [ i1A8] (FITC) - ab11709 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone i1A8
This image was kindly supplied as part of the review submitted by Brigitte Bauvois. Monocytes isolated from whole blood were stained with ab11709 (shaded histogram), isotype control (open histogram).

Anti-Angiotensin Converting Enzyme 1 antibody [2E2] - ab11734 from Abcam

Prices $378.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 2E2

Anti-Angiotensin Converting Enzyme 1 antibody [3C5] - ab11737 from Abcam

Prices $373.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 3C5

Anti-Angiotensin Converting Enzyme 1 antibody [9B9] - ab11738 from Abcam

Prices $375.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 9B9

Anti-Angiotensin Converting Enzyme 1 antibody [9B9] (Biotin) - ab11739 from Abcam

Prices $372.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 9B9

Anti-Angiotensin Converting Enzyme 1 antibody [9B9] (FITC) - ab11740 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 9B9
ab11740 staining CHO cells transfected with human Angiotensin Converting Enzyme by Flow Cytometry (FACS).

Anti-Angiotensin Converting Enzyme 1 antibody [9B9] (Phycoerythrin) - ab33318 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 9B9

Anti-Angiotensin Converting Enzyme 1 antibody [EPR2757] - ab75762 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2757
All lanes : Anti-Angiotensin Converting Enzyme 1 antibody [EPR2757] (ab75762) at 1/1000 dilutionLane 1 : fetal kidney lysateLane 2 : fetal heart lysateLane 3 : fetal lung lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Angiotensin Converting Enzyme 1 antibody [i2H5] (Biotin) - ab11735 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone i2H5

Anti-Angiotensin Converting Enzyme 1 antibody [i2H5] (FITC) - ab11736 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone i2H5
ab11736 Staining CHO cells transfected with human Angiotensin Converting Enzyme by Flow Cytometry (FACS).
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