MTM1

Gene Symbol	MTM1
Entrez Gene	4534
Alt Symbol	CNM, MTMX, XLMTM
Species	Human
Gene Type	protein-coding
Description	myotubularin 1
Other Description	myotubularin|phosphatidylinositol-3,5-bisphosphate 3-phosphatase|phosphatidylinositol-3-phosphate phosphatase
Swissprots	F2Z330 A6NDB1 Q13496 Q8NEL1 B7Z491
Accessions	AAC12865 EAW99377 EAW99378 EAW99379 EAW99380 Q13496 AK291710 BAF84399 AK297021 BAH12477 AK297057 BAH12485 AK304036 BAH14097 AL832715 BC030779 AAH30779 BQ002481 DC418907 JF432327 ADZ15544 U46024 AAC51682 XM_005274687 XP_005274744 XM_011531170 XP_011529472 XM_011531171 XP_011529473 XM_011531172 XP_011529474 XM_011531173 XP_011529475 NM_000252 NP_000243
Function	Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:9537414}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925}. Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:11001925}. Cell projection, filopodium {ECO:0000269|PubMed:12118066}. Cell projection, ruffle {ECO:0000269|PubMed:12118066}. Late endosome {ECO:0000269|PubMed:14722070}. Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation. {ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12118066}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

myotubularin (F-1) - sc-377309 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

myotubularin (C-18) - sc-14784 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

myotubularin (E-16) - sc-14783 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

myotubularin (T-16) - sc-14782 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

myotubularin (H-45) - sc-292993 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

myotubularin (N-20) - sc-14781 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

myotubularin (Y-12) - sc-100399 from Santa Cruz Biotechnology Host Mouse Clonality Monoclonal

Anti-MTM1 antibody - ab103626 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MTM1 antibody - ab55532 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MTM1 antibody - ab1350 from Abcam Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-MTM1 antibody - ab128318 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa573-602, AP) - LS-C263673 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa573-602, APC) - LS-C263674 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa573-602, Biotin) - LS-C263675 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa573-602, FITC) - LS-C263676 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa573-602, Azide-free, HRP) - LS-C263677 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa590-603) - LS-C55125 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa573-602, PE) - LS-C263678 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa573-602) - LS-C323155 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa241-290) - LS-C199929 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (N-Terminus) - LS-C146521 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (Tyr290) - LS-C177309 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody - LS-C330873 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody (aa566-594) - LS-C98436 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MTM1 / Myotubularin Antibody - LS-C192232 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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