MTM1

Gene Symbol	MTM1
Entrez Gene	4534
Alt Symbol	CNM, MTMX, XLMTM
Species	Human
Gene Type	protein-coding
Description	myotubularin 1
Other Description	myotubularin|phosphatidylinositol-3,5-bisphosphate 3-phosphatase|phosphatidylinositol-3-phosphate phosphatase
Swissprots	F2Z330 A6NDB1 Q13496 Q8NEL1 B7Z491
Accessions	AAC12865 EAW99377 EAW99378 EAW99379 EAW99380 Q13496 AK291710 BAF84399 AK297021 BAH12477 AK297057 BAH12485 AK304036 BAH14097 AL832715 BC030779 AAH30779 BQ002481 DC418907 JF432327 ADZ15544 U46024 AAC51682 XM_005274687 XP_005274744 XM_011531170 XP_011529472 XM_011531171 XP_011529473 XM_011531172 XP_011529474 XM_011531173 XP_011529475 NM_000252 NP_000243
Function	Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:9537414}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925}. Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:11001925}. Cell projection, filopodium {ECO:0000269|PubMed:12118066}. Cell projection, ruffle {ECO:0000269|PubMed:12118066}. Late endosome {ECO:0000269|PubMed:14722070}. Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation. {ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12118066}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MTM1 full length protein - ab158930 from Abcam Category Protein Source Wheat germ Species Human

Human MTM1 protein fragment - ab158931 from Abcam Category Protein Source Wheat germ Species Human

MTM1 / Myotubularin Antibody Blocking Peptide - LS-E20304 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MTM1 / Myotubularin Antibody Blocking Peptide - LS-E25250 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MTM1 / Myotubularin Antibody Blocking Peptide - LS-E8478 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Myotubularin Protein - H00004534-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Myotubularin Protein - H00004534-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Myotubularin Peptide - P2077 from Novus Biologicals Category Peptide Species Human

MTM1-Antibody-C-term-Blocking-Peptide - BP6809b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MTM1 blocking peptide - GTX89799-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

MTM1 Immunizing peptide - orb17255 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Myotubularin Blocking Peptide - abx062963 from Abbexa Category Peptide Species Human, Mouse

MTM1 Peptide - AC21-0077-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Myotubularin / MTM1 - H00004534-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Myotubularin / MTM1 - H00004534-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Myotubularin / MTM1 - H00004534-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Myotubularin / MTM1 - H00004534-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Myotubularin / MTM1 - H00004534-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MTM1 Peptide - 45-910P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

MTM1 fusion protein - Ag4940 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

MTM1 Peptide - 350537 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human MTM1, His-tagged - MTM1-1086H from Creative Biomart Category Protein Source E.coli Species Human

Myotubularin Blocking Peptide - CBP1769 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Myotubularin (Y290) Peptide - BS2971P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Myotubularin(MTM1) - CSB-YP614418HU CSB-EP614418HU CSB-BP614418HU CSB-MP614418HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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