MTM1

Gene Symbol	MTM1
Entrez Gene	4534
Alt Symbol	CNM, MTMX, XLMTM
Species	Human
Gene Type	protein-coding
Description	myotubularin 1
Other Description	myotubularin|phosphatidylinositol-3,5-bisphosphate 3-phosphatase|phosphatidylinositol-3-phosphate phosphatase
Swissprots	F2Z330 A6NDB1 Q13496 Q8NEL1 B7Z491
Accessions	AAC12865 EAW99377 EAW99378 EAW99379 EAW99380 Q13496 AK291710 BAF84399 AK297021 BAH12477 AK297057 BAH12485 AK304036 BAH14097 AL832715 BC030779 AAH30779 BQ002481 DC418907 JF432327 ADZ15544 U46024 AAC51682 XM_005274687 XP_005274744 XM_011531170 XP_011529472 XM_011531171 XP_011529473 XM_011531172 XP_011529474 XM_011531173 XP_011529475 NM_000252 NP_000243
Function	Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:9537414}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925}. Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:11001925}. Cell projection, filopodium {ECO:0000269|PubMed:12118066}. Cell projection, ruffle {ECO:0000269|PubMed:12118066}. Late endosome {ECO:0000269|PubMed:14722070}. Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation. {ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12118066}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

myotubularin 1, ELISA Kit - MBS9316983 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/ml. Range 3.12 ng/ml - 100 ng/ml.

Human Myotubularin ELISA Kit - EKE55163 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Range 0.312-20 ng/ml

Human MTM1 ELISA Kit - E025545 from Biobool Category ELISA Kit

MTM1 ELISA Kit (Human) (OKEH03510) - OKEH03510 from Aviva Systems Biology Category ELISA Kit Prices $485.00 Sizes 96 wells Sensitivity 0.156 ng/mL Range 0.312 - 20 ng/mL

Human Myotubularin ELISA Kit - EK3700 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Range 0.15 ng/ml -10.0 ng/ml

anti-MTM1 antibody - ARG63316 from Arigo Biolaboratories Category ELISA Kit

Human Myotubularin (MTM1) ELISA Kit - AE32441HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

Myotubularin (MTM1), ELISA Kit - MBS9359579 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9350135 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9374148 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9376504 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin, ELISA Kit - MBS2888035 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9368274 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9378099 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9360541 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9373984 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9353839 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9371013 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9368070 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9373417 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9356873 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9373934 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9355286 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin Related Protein (MTMR1), ELISA Kit - MBS9378775 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myotubularin (MTM1), ELISA Kit - MBS9345451 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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