GNB2L1

Gene Symbol GNB2L1
Entrez Gene 10399
Alt Symbol Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1
Species Human
Gene Type protein-coding
Description guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Other Description cell proliferation-inducing gene 21 protein|guanine nucleotide binding protein beta polypeptide 2-like 1|guanine nucleotide-binding protein subunit beta-2-like 1|guanine nucleotide-binding protein subunit beta-like protein 12.3|human lung cancer oncogene 7 protein|lung cancer oncogene 7|proliferation-inducing gene 21|protein homologous to chicken B complex protein, guanine nucleotide binding|receptor for activated C kinase 1|receptor of activated protein kinase C 1
Swissprots Q53HU2 Q6FH47 P63244 B3KTJ0 D3DWS0 Q5VLR4 Q5J8M6
Accessions EAW53692 EAW53693 EAW53694 EAW53695 EAW53696 EAW53697 EAW53698 EAW53699 EAW53700 EAW53701 EAW53702 P63244 AK095666 BAG53102 AK222488 BAD96208 AK301029 BAG62644 AK301468 BAG62988 AK303316 BAG64385 AK310916 AM393661 CAL38537 AY336089 AAR24619 BC000214 AAH00214 BC000366 AAH00366 BC010119 AAH10119 BC014256 AAH14256 BC014582 BC014788 AAH14788 BC017287 AAH17287 BC019093 AAH19093 BC019362 AAH19362 BC021993 AAH21993 BC029996 BC032006 AAH32006 BC035460 CR456978 CAG33259 CR541909 CAG46707 D28398 BAA05764 DQ891422 ABM82348 DQ894596 ABM85522 GU727632 ADU87634 JN104586 AFK13122 M24194 AAA59626 NM_006098 NP_006089
Function Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent
Subcellular Location Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis.
Tissue Specificity In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. {ECO:0000269|PubMed:18621736}.
Top Pathways Measles

RACK1 (D59D5) Rabbit mAb - 5432 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D59D5
Western blot analysis of extracts from various cell types using RACK1 (D59D5) Rabbit mAb.

RACK1 Antibody - 4716 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using RACK1 Antibody.

RACK1 (B-3) - sc-17754 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RACK1 (B-3): sc-17754. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon tumor showing cytoplasmic and membrane staining.

RACK1 (H-187) - sc-10775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RACK1 (H-187): sc-10775. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

RACK1 (I-18) - sc-12516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RACK1 antibody - ab72483 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab72483 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab72483, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-RACK1 antibody - ab62736 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RACK1 antibody (ab62736) at 1 µg/mlLane 1 : Extract from HEK-293T cell lineLane 2 : Extract from HeLa cell lineLane 3 : Extract from MCF7 cell lineLane 4 : Extract from U2OS cell lineLane 5 : Extract from Jurkat cell lineLane 6 : Extract from RAT1 cell lineLane 7 : Extract from PC12 cell lineLane 8 : Extract from NIH3T3 cell lineSecondaryGoat Anti-Rabbit IgGdeveloped using the ECL technique

Anti-RACK1 antibody - ab37672 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RACK1 antibody (ab37672) at 1/100 dilution + Ramos cell lysate.

Anti-RACK1 antibody [EPR7388] - ab129084 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7388
All lanes : Anti-RACK1 antibody [EPR7388] (ab129084) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : HeLa cell lysateLane 4 : PC12 cell lysateLane 5 : C6 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-GNB2L1 / RACK1 Antibody (aa88-137) - LS-C151445 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GNB2L1 / RACK1 antibody Western Blot of Mouse Liver.

Anti-GNB2L1 / RACK1 Antibody (N-Terminus, AP) - LS-C277700 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (N-Terminus, APC) - LS-C277702 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (N-Terminus, Biotin) - LS-C277703 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (N-Terminus, FITC) - LS-C277704 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (N-Terminus, Azide-free, HRP) - LS-C277705 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (N-Terminus, PE) - LS-C277706 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (aa1-50) - LS-C289280 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (N-Terminus) - LS-C327475 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody - LS-C341434 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (aa188-237) - LS-C170350 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GNB2L1 / RACK1 Antibody (Internal, clone EPR7388) - LS-C152475 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7388
IHC of paraffin-embedded human cervical carcinoma tissue using anti-RACK1 antibody.

Anti-GNB2L1 / RACK1 Antibody (aa29-58) - LS-C99963 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-GNB2L1 / RACK1 Antibody (Internal) - LS-C210469 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Prostate Carcinoma stained with anti-RACK-1 antibody

Anti-GNB2L1 / RACK1 Antibody - LS-C332164 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF-7 cell using GNB2L1 antibody.

Anti-GNB2L1 / RACK1 Antibody (aa133-147) IHC-plus™ - LS-B8352 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-GNB2L1 / RACK1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8352 dilution 3.75 ug/ml.
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