GNB2L1

Gene Symbol	GNB2L1
Entrez Gene	10399
Alt Symbol	Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1
Species	Human
Gene Type	protein-coding
Description	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Other Description	cell proliferation-inducing gene 21 protein|guanine nucleotide binding protein beta polypeptide 2-like 1|guanine nucleotide-binding protein subunit beta-2-like 1|guanine nucleotide-binding protein subunit beta-like protein 12.3|human lung cancer oncogene 7 protein|lung cancer oncogene 7|proliferation-inducing gene 21|protein homologous to chicken B complex protein, guanine nucleotide binding|receptor for activated C kinase 1|receptor of activated protein kinase C 1
Swissprots	Q53HU2 Q6FH47 P63244 B3KTJ0 D3DWS0 Q5VLR4 Q5J8M6
Accessions	EAW53692 EAW53693 EAW53694 EAW53695 EAW53696 EAW53697 EAW53698 EAW53699 EAW53700 EAW53701 EAW53702 P63244 AK095666 BAG53102 AK222488 BAD96208 AK301029 BAG62644 AK301468 BAG62988 AK303316 BAG64385 AK310916 AM393661 CAL38537 AY336089 AAR24619 BC000214 AAH00214 BC000366 AAH00366 BC010119 AAH10119 BC014256 AAH14256 BC014582 BC014788 AAH14788 BC017287 AAH17287 BC019093 AAH19093 BC019362 AAH19362 BC021993 AAH21993 BC029996 BC032006 AAH32006 BC035460 CR456978 CAG33259 CR541909 CAG46707 D28398 BAA05764 DQ891422 ABM82348 DQ894596 ABM85522 GU727632 ADU87634 JN104586 AFK13122 M24194 AAA59626 NM_006098 NP_006089
Function	Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent
Subcellular Location	Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis.
Tissue Specificity	In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. {ECO:0000269|PubMed:18621736}.
Top Pathways	Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), Human, ELISA Kit - CSB-EL009605HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), Human, ELISA Kit - E01G0433 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Guanine nucleotide binding protein subunit beta 2 like 1 (GNB2L1), ELISA Kit - MBS7200077 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

guanine nucleotide binding protein (G protein) , beta polypeptide 2-like 1, ELISA Kit - MBS936326 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human GNB2L1 is typically less than 11.75 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 47 pg/ml -3000 pg/ml.

Guanine nucleotide-binding protein subunit beta-2-like 1, ELISA Kit - MBS283081 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7250950 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7253534 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7218472 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7240744 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7219766 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7228996 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7212124 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7220575 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7215512 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7243973 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), ELISA Kit - MBS7225591 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Guanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1) ELISA kit - CSB-EL009605HU from Cusabio Category ELISA Kit Sensitivity 11.75 pg/ml Range 47 pg/ml-3000 pg/ml

Human GNB2L1 ELISA Kit - E017732 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human GNB2L1 is typically less than 11.75 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the

Human RACK1 ELISA Kit - E095218 from Biobool Category ELISA Kit

anti-RACK-1 antibody - ARG53515 from Arigo Biolaboratories Category ELISA Kit

anti-RACK-1 antibody (Ready-to-Use) - ARG53516 from Arigo Biolaboratories Category ELISA Kit

RACK1 ELISA Kit (Human) (OKCA01273) - OKCA01273 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 11.75 pg/mL Range 47 - 3,000 pg/mL

Human GNB2L1 ELISA Kit - orb406873 from Biorbyt Category ELISA Kit Sensitivity 11.75 pg/ml Range 47 pg/ml-3000 pg/ml

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