| Gene Symbol | GNB2L1 |
|---|---|
| Entrez Gene | 10399 |
| Alt Symbol | Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 |
| Other Description | cell proliferation-inducing gene 21 protein|guanine nucleotide binding protein beta polypeptide 2-like 1|guanine nucleotide-binding protein subunit beta-2-like 1|guanine nucleotide-binding protein subunit beta-like protein 12.3|human lung cancer oncogene 7 protein|lung cancer oncogene 7|proliferation-inducing gene 21|protein homologous to chicken B complex protein, guanine nucleotide binding|receptor for activated C kinase 1|receptor of activated protein kinase C 1 |
| Swissprots | Q53HU2 Q6FH47 P63244 B3KTJ0 D3DWS0 Q5VLR4 Q5J8M6 |
| Accessions | EAW53692 EAW53693 EAW53694 EAW53695 EAW53696 EAW53697 EAW53698 EAW53699 EAW53700 EAW53701 EAW53702 P63244 AK095666 BAG53102 AK222488 BAD96208 AK301029 BAG62644 AK301468 BAG62988 AK303316 BAG64385 AK310916 AM393661 CAL38537 AY336089 AAR24619 BC000214 AAH00214 BC000366 AAH00366 BC010119 AAH10119 BC014256 AAH14256 BC014582 BC014788 AAH14788 BC017287 AAH17287 BC019093 AAH19093 BC019362 AAH19362 BC021993 AAH21993 BC029996 BC032006 AAH32006 BC035460 CR456978 CAG33259 CR541909 CAG46707 D28398 BAA05764 DQ891422 ABM82348 DQ894596 ABM85522 GU727632 ADU87634 JN104586 AFK13122 M24194 AAA59626 NM_006098 NP_006089 |
| Function | Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent |
| Subcellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis. |
| Tissue Specificity | In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. {ECO:0000269|PubMed:18621736}. |
| Top Pathways | Measles |
RACK1 CRISPR/Cas9 KO Plasmid (h) - sc-400800 from Santa Cruz Biotechnology
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RACK1 HDR Plasmid (h) - sc-400800-HDR from Santa Cruz Biotechnology
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RACK1 Double Nickase Plasmid (h) - sc-400800-NIC from Santa Cruz Biotechnology
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RACK1 Double Nickase Plasmid (h2) - sc-400800-NIC-2 from Santa Cruz Biotechnology
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RACK1 CRISPR Activation Plasmid (h) - sc-400800-ACT from Santa Cruz Biotechnology
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RACK1 CRISPR Activation Plasmid (h2) - sc-400800-ACT-2 from Santa Cruz Biotechnology
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RACK1 Lentiviral Activation Particles (h) - sc-400800-LAC from Santa Cruz Biotechnology
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RACK1 Lentiviral Activation Particles (h2) - sc-400800-LAC-2 from Santa Cruz Biotechnology
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RACK1 siRNA (h) - sc-36354 from Santa Cruz Biotechnology
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RACK1 shRNA Plasmid (h) - sc-36354-SH from Santa Cruz Biotechnology
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RACK1 shRNA (h) Lentiviral Particles - sc-36354-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU102911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9419 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9419 from Sigma-Aldrich
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GNB2L1 siRNA (Human) - CRH7048 from Cohesion Biosciences
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GNB2L1 - MBS8231202 from MyBioSource
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shRNA set against Human GNB2L1 (NM_006098.4) - SHH304782 from Creative biogene
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shRNA set against Human GNB2L1(NM_006098.4) - SHH092117 from Creative biogene
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GNB2L1 shRNA Plasmid (Human) - CHH7048 from Cohesion Biosciences
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GNB2L1 miRNA 3'UTR clone - MiUTR1H-04109 from Creative biogene
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