| Gene Symbol | GPT |
|---|---|
| Entrez Gene | 2875 |
| Alt Symbol | AAT1, ALT1, GPT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamic-pyruvate transaminase (alanine aminotransferase) |
| Other Description | GPT 1|alanine aminotransferase 1|glutamate pyruvate transaminase 1|glutamic--alanine transaminase 1|glutamic--pyruvic transaminase 1|glutamic-alanine transaminase 1 |
| Swissprots | D3DWM7 P78398 B0YJ18 Q93076 P24298 |
| Accessions | AAC51155 ACA05996 CBF80470 CBU99504 EAW82077 EAW82078 EAW82079 P24298 AI283141 AK225562 AK298488 BAG60697 AK303779 BAG64738 BC018207 AAH18207 BP275218 BT006992 AAP35638 D10355 BAA01186 DQ890596 ABM92213 DQ893764 ABM84690 XM_011516993 XP_011515295 NM_005309 NP_005300 |
| Function | Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. {ECO:0000269|PubMed:11863375}. |
| Top Pathways | Alanine, aspartate and glutamate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism |