Gene Symbol | GPT |
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Entrez Gene | 2875 |
Alt Symbol | AAT1, ALT1, GPT1 |
Species | Human |
Gene Type | protein-coding |
Description | glutamic-pyruvate transaminase (alanine aminotransferase) |
Other Description | GPT 1|alanine aminotransferase 1|glutamate pyruvate transaminase 1|glutamic--alanine transaminase 1|glutamic--pyruvic transaminase 1|glutamic-alanine transaminase 1 |
Swissprots | D3DWM7 P78398 B0YJ18 Q93076 P24298 |
Accessions | AAC51155 ACA05996 CBF80470 CBU99504 EAW82077 EAW82078 EAW82079 P24298 AI283141 AK225562 AK298488 BAG60697 AK303779 BAG64738 BC018207 AAH18207 BP275218 BT006992 AAP35638 D10355 BAA01186 DQ890596 ABM92213 DQ893764 ABM84690 XM_011516993 XP_011515295 NM_005309 NP_005300 |
Function | Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. {ECO:0000269|PubMed:11863375}. |
Top Pathways | Alanine, aspartate and glutamate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism |
GPT CRISPR/Cas9 KO Plasmid (h) - sc-402909 from Santa Cruz Biotechnology
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GPT HDR Plasmid (h) - sc-402909-HDR from Santa Cruz Biotechnology
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GPT Double Nickase Plasmid (h) - sc-402909-NIC from Santa Cruz Biotechnology
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GPT Double Nickase Plasmid (h2) - sc-402909-NIC-2 from Santa Cruz Biotechnology
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GPT CRISPR Activation Plasmid (h) - sc-402909-ACT from Santa Cruz Biotechnology
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GPT CRISPR Activation Plasmid (h2) - sc-402909-ACT-2 from Santa Cruz Biotechnology
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GPT Lentiviral Activation Particles (h) - sc-402909-LAC from Santa Cruz Biotechnology
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GPT Lentiviral Activation Particles (h2) - sc-402909-LAC-2 from Santa Cruz Biotechnology
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GPT siRNA (h) - sc-60753 from Santa Cruz Biotechnology
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GPT shRNA Plasmid (h) - sc-60753-SH from Santa Cruz Biotechnology
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GPT shRNA (h) Lentiviral Particles - sc-60753-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU140281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9643 from Sigma-Aldrich
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GPT siRNA (Human) - CRH1932 from Cohesion Biosciences
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GPT - MBS8227977 from MyBioSource
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shRNA set against Human GPT (NM_005309.2) - SHH307338 from Creative biogene
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Human GPT siRNA - orb262434 from Biorbyt
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GPT shRNA Plasmid (Human) - CHH1932 from Cohesion Biosciences
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