| Gene Symbol |
GPT
|
| Entrez Gene |
2875
|
| Alt Symbol |
AAT1, ALT1, GPT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamic-pyruvate transaminase (alanine aminotransferase)
|
| Other Description |
GPT 1|alanine aminotransferase 1|glutamate pyruvate transaminase 1|glutamic--alanine transaminase 1|glutamic--pyruvic transaminase 1|glutamic-alanine transaminase 1
|
| Swissprots |
D3DWM7 P78398 B0YJ18 Q93076 P24298
|
| Accessions |
AAC51155 ACA05996 CBF80470 CBU99504 EAW82077 EAW82078 EAW82079 P24298 AI283141 AK225562 AK298488 BAG60697 AK303779 BAG64738 BC018207 AAH18207 BP275218 BT006992 AAP35638 D10355 BAA01186 DQ890596 ABM92213 DQ893764 ABM84690 XM_011516993 XP_011515295 NM_005309 NP_005300
|
| Function |
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. {ECO:0000269|PubMed:11863375}.
|
| Top Pathways |
Alanine, aspartate and glutamate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism
|