| Gene Symbol |
CERS3
|
| Entrez Gene |
204219
|
| Alt Symbol |
ARCI9, LASS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ceramide synthase 3
|
| Other Description |
LAG1 homolog, ceramide synthase 3|LAG1 longevity assurance homolog 3|dihydroceramide synthase 3
|
| Swissprots |
Q8IU89 Q8NE64 Q8NEN6
|
| Accessions |
EAX02267 EAX02268 EAX02269 Q8IU89 AK307191 BC027616 BC028703 AAH28703 BC034500 AAH34500 BC034970 AAH34970 DQ890899 ABM81825 EU176496 ABW03297 HY022150 XM_011521355 XP_011519657 XM_011521356 XP_011519658 XM_011521357 XP_011519659 XM_011521358 XP_011519660 NM_001290341 NP_001277270 NM_001290342 NP_001277271 NM_001290343 NP_001277272 NM_178842 NP_849164
|
| Function |
Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation. {ECO:0000250, ECO:0000269|PubMed:23754960}.
|
| Subcellular Location |
Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level). {ECO:0000269|PubMed:23754960}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|