CERS3

Gene Symbol	CERS3
Entrez Gene	204219
Alt Symbol	ARCI9, LASS3
Species	Human
Gene Type	protein-coding
Description	ceramide synthase 3
Other Description	LAG1 homolog, ceramide synthase 3|LAG1 longevity assurance homolog 3|dihydroceramide synthase 3
Swissprots	Q8IU89 Q8NE64 Q8NEN6
Accessions	EAX02267 EAX02268 EAX02269 Q8IU89 AK307191 BC027616 BC028703 AAH28703 BC034500 AAH34500 BC034970 AAH34970 DQ890899 ABM81825 EU176496 ABW03297 HY022150 XM_011521355 XP_011519657 XM_011521356 XP_011519658 XM_011521357 XP_011519659 XM_011521358 XP_011519660 NM_001290341 NP_001277270 NM_001290342 NP_001277271 NM_001290343 NP_001277272 NM_178842 NP_849164
Function	Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation. {ECO:0000250, ECO:0000269|PubMed:23754960}.
Subcellular Location	Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level). {ECO:0000269|PubMed:23754960}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LASS3 protein fragment - ab165906 from Abcam Category Protein Source Wheat germ Species Human

LASS3 Antibody Blocking Peptide - LS-E11061 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LASS3 Antibody Blocking Peptide - LS-E26827 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LASS3 Protein - H00204219-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LASS3/CerS3 blocking peptide - GTX88586-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Lass3 peptide - orb108425 from Biorbyt Category Peptide Prices $298.00 Sizes 50 μg Species Human

LASS3 Peptide - AC21-1659-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LASS3 - H00204219-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LASS3 - H00204219-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LASS3 Control Peptide - AP05283CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

LASS3 Peptide - 46-723P from ProSci Category Peptide Species Rat

LASS3 fusion protein - ag14099 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

LASS3 fusion protein - Ag14513 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CERS3 Peptide (OEEG01142) - OEEG01142 from Aviva Systems Biology Category Peptide Prices $150.00 Sizes 50 µg Species Human

LASS3 - TP305511 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Lass3, Peptide - MBS396437 from MyBioSource Category Peptide Prices $195.00 Sizes 50 µg Species Human

LASS3/CerS3, Peptide - MBS426667 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

LASS3 Recombinant Protein Antigen - NBP1-84536PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LASS3 Recombinant Protein Antigen - NBP1-84535PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CERS3 Peptide, Human - M34GP03015H from Creative Peptides Category Peptide Source Synthetic. Species Human

Ceramide synthase 3 (CERS3), Recombinant Protein - MBS7011388 from MyBioSource Category Protein Prices $1,190.00, $2,175.00, $3,385.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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