CERS3

Gene Symbol CERS3
Entrez Gene 204219
Alt Symbol ARCI9, LASS3
Species Human
Gene Type protein-coding
Description ceramide synthase 3
Other Description LAG1 homolog, ceramide synthase 3|LAG1 longevity assurance homolog 3|dihydroceramide synthase 3
Swissprots Q8IU89 Q8NE64 Q8NEN6
Accessions EAX02267 EAX02268 EAX02269 Q8IU89 AK307191 BC027616 BC028703 AAH28703 BC034500 AAH34500 BC034970 AAH34970 DQ890899 ABM81825 EU176496 ABW03297 HY022150 XM_011521355 XP_011519657 XM_011521356 XP_011519658 XM_011521357 XP_011519659 XM_011521358 XP_011519660 NM_001290341 NP_001277270 NM_001290342 NP_001277271 NM_001290343 NP_001277272 NM_178842 NP_849164
Function Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation. {ECO:0000250, ECO:0000269|PubMed:23754960}.
Subcellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level). {ECO:0000269|PubMed:23754960}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

LASS3 CRISPR/Cas9 KO Plasmid (h) - sc-409070 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 HDR Plasmid (h) - sc-409070-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 Double Nickase Plasmid (h) - sc-409070-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 Double Nickase Plasmid (h2) - sc-409070-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 CRISPR Activation Plasmid (h) - sc-409070-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 CRISPR Activation Plasmid (h2) - sc-409070-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 Lentiviral Activation Particles (h) - sc-409070-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 Lentiviral Activation Particles (h2) - sc-409070-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LASS3 siRNA (h) - sc-62547 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LASS3 shRNA Plasmid (h) - sc-62547-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LASS3 shRNA (h) Lentiviral Particles - sc-62547-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LASS3 RNAi - H00204219-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU131751 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11562 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11562 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11280 from Sigma-Aldrich

Category miRNA

CERS3 siRNA (Human) - CRJ6352 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CERS3 - MBS8217752 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Cers3 (NM_178842.3) - SHH262121 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LASS3(NM_178842.3) - SHH142931 from Creative biogene

Category siRNA
Species Reactivities Human

Human CERS3 siRNA - orb276853 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CERS3 shRNA Plasmid (Human) - CHJ6352 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CERS3 miRNA 3'UTR clone - MiUTR1H-05582 from Creative biogene

Species Reactivities Human
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