COMMD1

Gene Symbol	COMMD1
Entrez Gene	150684
Alt Symbol	C2orf5, MURR1
Species	Human
Gene Type	protein-coding
Description	copper metabolism (Murr1) domain containing 1
Other Description	COMM domain-containing protein 1|copper metabolism gene MURR1|protein Murr1
Swissprots	B4DFQ4 Q8N668 Q96GS0
Accessions	AAX93080 AAY24054 AAY24141 EAW99981 Q8N668 AB178811 BAD18972 AK223607 BAD97327 AK294203 BAG57515 BC009266 AAH09266 BC022046 AAH22046 BG182961 BG183486 BG215225 D85433 HQ447741 ADQ32226 XM_005264157 XP_005264214 XM_011532558 XP_011530860 XM_011532559 XP_011530861 XM_011532560 XP_011530862 NM_152516 NP_689729
Function	Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes
Subcellular Location	Nucleus {ECO:0000269|PubMed:21778237}. Cytoplasm {ECO:0000269|PubMed:21778237}. Endosome membrane {ECO:0000269|PubMed:18940794}. Cytoplasmic vesicle {ECO:0000269|PubMed:18940794}. Early endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:25355947}. Recycling endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370}. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
Tissue Specificity	Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Down- regulated in cancer tissues. {ECO:0000269|PubMed:11809725, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:20458141}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COMMD1/MURR1 full length protein - ab98077 from Abcam Category Protein Source E. coli Species Human

Human COMMD1/MURR1 full length protein - ab117654 from Abcam Category Protein Source E. coli Species Human

COMMD1 Antibody Blocking Peptide - LS-E22530 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COMMD1 Recombinant Protein - H00150684-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

COMMD1 Partial Recombinant Protein - H00150684-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human COMMD1 Protein - NBP1-50846 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

COMMD1 Protein (OPPA02276) - OPPA02276 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human COMMD1 protein - orb81041 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

COMMD1 Blocking Peptide - 33R-6261 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

COMMD1 protein (His tag) - 80R-1392 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

COMMD1 (1-190, His-tag) - AR09567PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

COMMD1 (1-190, His-tag) - AR09567PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

COMMD1 - H00150684-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

COMMD1 - H00150684-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COMMD1 - H00150684-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

COMMD1 - H00150684-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COMMD1, 1-190aa, Human, His tag, E.coli - 01-1882-1 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

COMMD1 fusion protein - ag2535 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

COMMD1 Human - PRPS-869 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Copper Metabolism Domain Containing 1 Protein - BP001542-PRO-862 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

COMMD1, 1-190aa, Recombinant Protein - GWB-P1408D from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

COMMD1 Human Protein - GWB-BSP435 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human COMMD1, His-tagged - COMMD1-2732H from Creative Biomart Category Protein Source E.coli.

Recombinant Human COMMD1, His-tagged - COMMD1-28013TH from Creative Biomart Category Protein Source E. coli

Recombinant Human COMMD1, His-tagged - COMMD1-28014TH from Creative Biomart Category Protein Source E. coli

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