COMMD1

Gene Symbol	COMMD1
Entrez Gene	150684
Alt Symbol	C2orf5, MURR1
Species	Human
Gene Type	protein-coding
Description	copper metabolism (Murr1) domain containing 1
Other Description	COMM domain-containing protein 1\|copper metabolism gene MURR1\|protein Murr1
Swissprots	B4DFQ4 Q8N668 Q96GS0
Accessions	AAX93080 AAY24054 AAY24141 EAW99981 Q8N668 AB178811 BAD18972 AK223607 BAD97327 AK294203 BAG57515 BC009266 AAH09266 BC022046 AAH22046 BG182961 BG183486 BG215225 D85433 HQ447741 ADQ32226 XM_005264157 XP_005264214 XM_011532558 XP_011530860 XM_011532559 XP_011530861 XM_011532560 XP_011530862 NM_152516 NP_689729
Function	Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes
Subcellular Location	Nucleus {ECO:0000269\|PubMed:21778237}. Cytoplasm {ECO:0000269\|PubMed:21778237}. Endosome membrane {ECO:0000269\|PubMed:18940794}. Cytoplasmic vesicle {ECO:0000269\|PubMed:18940794}. Early endosome {ECO:0000269\|PubMed:21483833, ECO:0000269\|PubMed:25355947}. Recycling endosome {ECO:0000269\|PubMed:21483833, ECO:0000269\|PubMed:21741370}. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
Tissue Specificity	Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Down- regulated in cancer tissues. {ECO:0000269\|PubMed:11809725, ECO:0000269\|PubMed:15799966, ECO:0000269\|PubMed:16573520, ECO:0000269\|PubMed:20458141}.

COMMD1 (B-4) - sc-166248 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

COMMD1 (B-4): sc-166248. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic and nuclear localization.

COMMD1 (E-13) - sc-107497 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

COMMD1 (H-140) - sc-98286 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

COMMD1 (B-4): sc-98286. Western blot analysis of COMMD1 expression in mouse liver tissue extract.

COMMD1 (K-13) - sc-107498 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

COMMD1 (K-13): sc-107498. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

COMMD1 (W-13) - sc-107500 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-COMMD1/MURR1 antibody - ab102794 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-COMMD1/MURR1 antibody (ab102794) at 1/500 dilution + Mouse liver tissue lysate at 50 µg

Anti-COMMD1/MURR1 antibody - ab199878 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-COMMD1/MURR1 antibody (ab199878) at 1/1000 dilutionLane 1 : mouse thymus total cell extractLane 2 : HeLa total cell extractLane 3 : Jurkat total cell extract

Anti-COMMD1/MURR1 antibody - ab89072 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Anti-COMMD1/MURR1 antibody (ab89072) at 1/500 dilution + Human placenta tissue lysate at 50 µg

Anti-COMMD1/MURR1 antibody - ab58322 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-COMMD1/MURR1 antibody - ab116275 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-COMMD1/MURR1 antibody (ab116275) at 1 µg/ml + Mouse heart lysate at 10 µg

Anti-COMMD1/MURR1 antibody - ab104869 from Abcam

Prices	$370.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-COMMD1/MURR1 antibody [1G7] - ab128111 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1G7

All lanes : Anti-COMMD1/MURR1 antibody [1G7] (ab128111) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY COMMD1/MURR1 cDNALysates/proteins at 5 µg per lane.

Anti-COMMD1/MURR1 antibody [3B3] - ab131597 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3B3

All lanes : Anti-COMMD1/MURR1 antibody [3B3] (ab131597) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cells transfected with pCMV6-ENTRY COMMD1/MURR1 cDNA Lysates/proteins at 5 µg per lane.SecondaryGoat anti-mouse-HRP at 5000

Anti-COMMD1 Antibody - LS-C346255 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Immunofluorescence blot of A549 cell using COMMD1 antibody. Blue: DAPI for nuclear staining.

Anti-COMMD1 Antibody (clone 1C3) - LS-C337776 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	1C3

IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-COMMD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-COMMD1 Antibody (clone 3B3) - LS-C174030 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	3B3

IHC of paraffin-embedded Human Kidney tissue using anti-COMMD1 mouse monoclonal antibody.

Anti-COMMD1 Antibody (clone 2D10) - LS-C337781 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2D10

Anti-COMMD1 Antibody (clone 1F2) - LS-C337778 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	1F2

IHC of paraffin-embedded Human Kidney tissue using anti-COMMD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-COMMD1 Antibody (clone 1G7) - LS-C174047 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	1G7

IHC of paraffin-embedded Human tonsil using anti-COMMD1 mouse monoclonal antibody.

Anti-COMMD1 Antibody (clone 2E2) IHC-plus™ - LS-B11735 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2E2

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-COMMD1 Antibody (Internal) - LS-C145149 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COMMD1 Antibody (aa1-191, clone 10B2565, Azide-free) - LS-C183529 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	10B2565

Anti-COMMD1 Antibody (aa110-159) - LS-C145415 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

COMMD1 antibody LS-C145415 Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.

Anti-COMMD1 Antibody - LS-C309960 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COMMD1 Antibody - LS-C307043 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Search more