| Gene Symbol |
DENND1A
|
| Entrez Gene |
57706
|
| Alt Symbol |
FAM31A, KIAA1608
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DENN/MADD domain containing 1A
|
| Other Description |
DENN domain-containing protein 1A|connecdenn 1
|
| Swissprots |
Q6PJZ5 B7Z669 D3PFD3 Q9H796 Q8TEH3 B7Z3C8 Q5VWF0 A8MZA3 B1AM80 Q05C88 Q8IVD6
|
| Accessions |
EAW87569 EAW87570 EAW87571 EAW87572 EAW87573 EAW87574 EAW87575 Q8TEH3 AB046828 BAB13434 AK024782 BAB15002 AK074151 BAB84977 AK225104 AK295710 BAH12164 AK299867 BAH13155 BC009616 AAH09616 BC028061 AAH28061 BC039703 AAH39703 BK006958 DAA12500 JF432807 ADZ16024 XM_005252109 XP_005252166 XM_005252111 XP_005252168 XM_005252113 XP_005252170 XM_006717195 XP_006717258 XM_011518882 XP_011517184 XM_011518883 XP_011517185 XM_011518884 XP_011517186 XM_011518885 XP_011517187 XM_011518886 XP_011517188 XM_011518887 XP_011517189 XR_929829 XR_929830 NM_020946 NP_065997 NM_024820 NP_079096
|
| Function |
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.
|
| Subcellular Location |
Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:20937701}; Peripheral membrane protein {ECO:0000269|PubMed:20937701}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:20937701}.
|
![Western Blot: DENND1A Overexpression Lysate (Adult Normal) [NBL1-09827] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DENND1A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/704_DENND1A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09827-img0002.jpg)