Gene Symbol | DENND1A |
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Entrez Gene | 57706 |
Alt Symbol | FAM31A, KIAA1608 |
Species | Human |
Gene Type | protein-coding |
Description | DENN/MADD domain containing 1A |
Other Description | DENN domain-containing protein 1A|connecdenn 1 |
Swissprots | Q6PJZ5 B7Z669 D3PFD3 Q9H796 Q8TEH3 B7Z3C8 Q5VWF0 A8MZA3 B1AM80 Q05C88 Q8IVD6 |
Accessions | EAW87569 EAW87570 EAW87571 EAW87572 EAW87573 EAW87574 EAW87575 Q8TEH3 AB046828 BAB13434 AK024782 BAB15002 AK074151 BAB84977 AK225104 AK295710 BAH12164 AK299867 BAH13155 BC009616 AAH09616 BC028061 AAH28061 BC039703 AAH39703 BK006958 DAA12500 JF432807 ADZ16024 XM_005252109 XP_005252166 XM_005252111 XP_005252168 XM_005252113 XP_005252170 XM_006717195 XP_006717258 XM_011518882 XP_011517184 XM_011518883 XP_011517185 XM_011518884 XP_011517186 XM_011518885 XP_011517187 XM_011518886 XP_011517188 XM_011518887 XP_011517189 XR_929829 XR_929830 NM_020946 NP_065997 NM_024820 NP_079096 |
Function | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
Subcellular Location | Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:20937701}; Peripheral membrane protein {ECO:0000269|PubMed:20937701}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:20937701}. |
DENND1A CRISPR/Cas9 KO Plasmid (h) - sc-412883 from Santa Cruz Biotechnology
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DENND1A HDR Plasmid (h) - sc-412883-HDR from Santa Cruz Biotechnology
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DENND1A Double Nickase Plasmid (h) - sc-412883-NIC from Santa Cruz Biotechnology
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DENND1A Double Nickase Plasmid (h2) - sc-412883-NIC-2 from Santa Cruz Biotechnology
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DENND1A CRISPR Activation Plasmid (h) - sc-412883-ACT from Santa Cruz Biotechnology
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DENND1A CRISPR Activation Plasmid (h2) - sc-412883-ACT-2 from Santa Cruz Biotechnology
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DENND1A Lentiviral Activation Particles (h) - sc-412883-LAC from Santa Cruz Biotechnology
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DENND1A Lentiviral Activation Particles (h2) - sc-412883-LAC-2 from Santa Cruz Biotechnology
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DENND1A siRNA (h) - sc-92634 from Santa Cruz Biotechnology
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DENND1A shRNA Plasmid (h) - sc-92634-SH from Santa Cruz Biotechnology
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DENND1A shRNA (h) Lentiviral Particles - sc-92634-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU080331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7135 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7135 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10696 from Sigma-Aldrich
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DENND1A siRNA (Human) - CRJ1648 from Cohesion Biosciences
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DENND1A - MBS8219495 from MyBioSource
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shRNA set against Human DENND1A (NM_024820.2) - SHH277005 from Creative biogene
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shRNA set against Human DENND1A(NM_020946.1) - SHH001243 from Creative biogene
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Human DENND1A siRNA - orb272149 from Biorbyt
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DENND1A shRNA Plasmid (Human) - CHJ1648 from Cohesion Biosciences
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DENND1A miRNA 3'UTR clone - MiUTR1H-02769 from Creative biogene
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DENND1A miRNA 3'UTR clone - MiUTR1H-02770 from Creative biogene
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