| Gene Symbol | NLGN2 |
|---|---|
| Entrez Gene | 57555 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | neuroligin 2 |
| Other Description | neuroligin-2 |
| Swissprots | Q9P2I1 Q8NFZ4 |
| Accessions | EAW90195 EAW90196 EAW90197 Q8NFZ4 AA447769 AB037787 BAA92604 AF376802 AAM46111 AI613237 BC069217 BC172284 AAI72284 BI868885 BM800364 DR763679 EL949788 XM_005256744 XP_005256801 NM_020795 NP_065846 |
| Function | Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secreti |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}. |
| Top Pathways | Cell adhesion molecules (CAMs) |