NLGN2

Gene Symbol NLGN2
Entrez Gene 57555
Alt Symbol -
Species Human
Gene Type protein-coding
Description neuroligin 2
Other Description neuroligin-2
Swissprots Q9P2I1 Q8NFZ4
Accessions EAW90195 EAW90196 EAW90197 Q8NFZ4 AA447769 AB037787 BAA92604 AF376802 AAM46111 AI613237 BC069217 BC172284 AAI72284 BI868885 BM800364 DR763679 EL949788 XM_005256744 XP_005256801 NM_020795 NP_065846
Function Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secreti
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}.
Top Pathways Cell adhesion molecules (CAMs)

neuroligin 2 (R-16) - sc-14089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
neuroligin 2 (R-16): sc-14089. Western blot analysis of neuroligin 2 expression in EOC 20 (A) and BC<sub>3</sub>H1 (B) whole cell lysates.

neuroligin 2 (H-40) - sc-50394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

neuroligin 2 (D-15) - sc-14087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Neuroligin 2 antibody - ab36602 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC-FoFr image of Neuroligin 2 (ab36602) staining on Rat Spinal Cord. The sections used came from animals perfused fixed with Paraformaldehyde 4%, in phosphate buffer 0.2M. Following postfixation in the same fixative overnight, the tissues were cryoprotected in sucrose 30% overnight. Tissues were then cut using a cryostat and the immunostainings were preformed using the ‘free floating’ technique. Image A shows the staining observed at the level of the lateral part of the dorsal horn, showing stained lamina II neurons (arrows). Image B shows the staining observed lamina X. See Abreview

Anti-Neuroligin 2 antibody - ab77595 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Neuroligin 2 antibody (ab77595) at 0.1 µg/ml + Human Pancreas lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-Neuroligin 2 antibody - ab177107 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Neuroligin 2 antibody (ab177107) at 1/500 dilution + HeLa lysate

Anti-NLGN2 / Neuroligin 2 Antibody (C-Terminus) IHC-plus™ - LS-B12132 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of NLGN2 in mouse brain tissue with NLGN2 antibody at 5 ug/ml.

Anti-NLGN2 / Neuroligin 2 Antibody (aa165-177) IHC-plus™ - LS-B10289 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-NLGN2 / Neuroligin 2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10289 concentration 5 ug/ml.

Anti-NLGN2 / Neuroligin 2 Antibody (aa15-660) - LS-C125994 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Neuroligin 2/NLGN2 Antibody - AF5645 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot Neuroligin 2/NLGN2 Antibody

Neuroligin 2/NLGN2 Antibody - NBP1-00220 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Neuroligin 2/NLGN2 Antibody [NBP1-00220] - Analysis of Neuroligin 2 in Human Pancreas lysate (35ug protein in RIPA buffer) using this antibody at 0.1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Neuroligin 2/NLGN2 Antibody - NBP2-41299 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Neuroligin 2/NLGN2 Antibody [NBP2-41299] - Western blot analysis of NLGN2 in rat brain tissue lysate with NLGN2 antibody at (A) 1 and (B) 2 ug/ml.

NLGN2 Antibody - C-terminal region (ARP49572_P050) - ARP49572_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Neuroligin-2-Antibody - AF1723a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1723a (0.1 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Neuroligin 2 antibody, Internal - GTX89107 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-Neuroligin 2 antibody, Internal used in Western blot. GTX89107

Neuroligin 1 + Neuroligin 2 antibody - GTX51022 from GeneTex

Prices $319.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Anti-NLGN2 antibody used in ELISA. GTX51022

Human/Rat Neuroligin 2/NLGN2 Antibody - AF5645 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Detection of Human and Rat Neuroligin 2/NLGN2 by Western Blot. Western blot shows lysates of human cortex and rat cerebellum tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Rat Neuroligin 2/NLGN2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5645) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019 ). A specific band was detected for Neuroligin 2/ NLGN2 at approximately XXX kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8 .
Detection of Human and Rat Neuroligin 2/NLGN2 by Western Blot.Western blot shows lysates of human cortex and rat cerebellum tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Rat Neuroligin 2/NLGN2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5645) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Neuroligin 2/NLGN2 at approximately XXX kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

NLGN2 Antibody (OAEB02275) - OAEB02275 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

NLGN2 Antibody - abx037651 from Abbexa

Host Rabbit
Clonality Polyclonal

Neuroligin-2 antibody - AP16611PU-N from Acris Antibodies

Prices $310.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AP16611PU-N (0.1µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Neuroligin 2 Antibody - AC21-1114 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-Neuroligin 2 Antibody (AMCA) - AC21-1114-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-Neuroligin 2 Antibody (AP) - AC21-1114-02 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-Neuroligin 2 Antibody (APC) - AC21-1114-03 from Abcore

Prices $515.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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