NLGN2

Gene Symbol	NLGN2
Entrez Gene	57555
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	neuroligin 2
Other Description	neuroligin-2
Swissprots	Q9P2I1 Q8NFZ4
Accessions	EAW90195 EAW90196 EAW90197 Q8NFZ4 AA447769 AB037787 BAA92604 AF376802 AAM46111 AI613237 BC069217 BC172284 AAI72284 BI868885 BM800364 DR763679 EL949788 XM_005256744 XP_005256801 NM_020795 NP_065846
Function	Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secreti
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Neuroligin 2 peptide - ab36601 from Abcam Category Peptide

NLGN2 / Neuroligin 2 Antibody Blocking Peptide - LS-E26282 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NLGN2-Antibody-C-term-Blocking-Peptide - BP16943b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Neuroligin 2 blocking peptide - GTX89107-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human Neuroligin 2/NLGN2, CF - 5645-NL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln15-Ser660, with a C-terminal 6-His tag

NLGN2 Immunizing peptide - orb17312 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Neuroligin 2 Peptide - AC21-1114-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Neuroligin 2 Peptide - 46-693P from ProSci Category Peptide Species Human, Rat

NLGN2 Peptide - 7969P from ProSci Category Peptide

Recombinant Human Neuroligin 2, His-tagged - NLGN2-5692H from Creative Biomart Category Protein Source Murine myeloma cellline, NS0-derived.

Recombinant Human NLGN2, His-tagged - NLGN2-531H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Human Neuroligin-2(NLGN2) - CSB-YP839877HU CSB-EP839877HU CSB-BP839877HU CSB-MP839877HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Neuroligin 2/NLGN2 Protein, CF - 5645-NL from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Gln15-Ser660, with a C-terminal 6-His tag Species Human

Neuroligin 2, Peptide - MBS425216 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

Neuroligin 2, Peptide - MBS658618 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg Species Human, Rat, Dog

Neuroligin 2/NLGN2 Recombinant Protein Antigen - NBP2-49590PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

NLGN2 Peptide, Human - M34GP10423H from Creative Peptides Category Peptide Source Synthetic. Species Human

Neuroligin 2/NLGN2 Recombinant Protein Antigen - NBP2-56665PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Neuroligin-2 (NLGN2), Recombinant Protein - MBS1283738 from MyBioSource Category Protein Prices $1,465.00, $1,465.00, $1,695.00, $1,695.00, $2,490.00, $2,490.00, $2,935.00, $2,935.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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