| Gene Symbol | CCNL1 |
|---|---|
| Entrez Gene | 57018 |
| Alt Symbol | ANIA6A, BM-001, PRO1073, ania-6a |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin L1 |
| Other Description | cyclin L ania-6a|cyclin L gamma|cyclin-L|cyclin-L1 |
| Swissprots | Q9NZF3 Q96QT0 Q6UWS7 Q8NI48 B3KMY3 Q9UK58 Q6NVY9 |
| Accessions | CBX53839 EAW78712 EAW78713 EAW78714 Q9UK58 AF180920 AAD53184 AF208843 AAF64257 AF367476 AAM21204 AF367477 AAM21205 AK022974 BAG51145 AK098021 AK122738 AK125606 AY034790 AAK61551 AY358663 AAQ89026 BC007081 AAH07081 BC038394 AAH38394 BC067812 AAH67812 BQ024284 BQ027163 BX641146 BX647554 JF432881 ADZ16098 XM_005247647 XP_005247704 XM_005247648 XP_005247705 XM_005247649 XP_005247706 XM_005247650 XP_005247707 XM_005247651 XP_005247708 XM_006713710 XP_006713773 XM_011513011 XP_011511313 NM_001308185 NP_001295114 NM_020307 NP_064703 |
| Function | Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036}. |
| Subcellular Location | Nucleus speckle {ECO:0000250}. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036}. |
cyclin L1 CRISPR/Cas9 KO Plasmid (h) - sc-406738 from Santa Cruz Biotechnology
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cyclin L1 HDR Plasmid (h) - sc-406738-HDR from Santa Cruz Biotechnology
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cyclin L1 Double Nickase Plasmid (h) - sc-406738-NIC from Santa Cruz Biotechnology
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cyclin L1 Double Nickase Plasmid (h2) - sc-406738-NIC-2 from Santa Cruz Biotechnology
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cyclin L1 CRISPR Activation Plasmid (h) - sc-406738-ACT from Santa Cruz Biotechnology
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cyclin L1 CRISPR Activation Plasmid (h2) - sc-406738-ACT-2 from Santa Cruz Biotechnology
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cyclin L1 Lentiviral Activation Particles (h) - sc-406738-LAC from Santa Cruz Biotechnology
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cyclin L1 Lentiviral Activation Particles (h2) - sc-406738-LAC-2 from Santa Cruz Biotechnology
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cyclin L1 siRNA (h) - sc-44902 from Santa Cruz Biotechnology
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cyclin L1 shRNA Plasmid (h) - sc-44902-SH from Santa Cruz Biotechnology
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cyclin L1 shRNA (h) Lentiviral Particles - sc-44902-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5646 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5646 from Sigma-Aldrich
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CCNL1 siRNA (Human) - CRJ1290 from Cohesion Biosciences
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CCNL1 - MBS8215791 from MyBioSource
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shRNA set against Human CCNL1 (NM_020307.2) - SHH258005 from Creative biogene
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shRNA set against Human CCNL1(NM_020307.2) - SHG152789 from Creative biogene
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Human CCNL1 siRNA - orb271791 from Biorbyt
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CCNL1 shRNA Plasmid (Human) - CHJ1290 from Cohesion Biosciences
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CCNL1 miRNA 3'UTR clone - MiUTR1H-01822 from Creative biogene
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