CCNL1

Gene Symbol CCNL1
Entrez Gene 57018
Alt Symbol ANIA6A, BM-001, PRO1073, ania-6a
Species Human
Gene Type protein-coding
Description cyclin L1
Other Description cyclin L ania-6a|cyclin L gamma|cyclin-L|cyclin-L1
Swissprots Q9NZF3 Q96QT0 Q6UWS7 Q8NI48 B3KMY3 Q9UK58 Q6NVY9
Accessions CBX53839 EAW78712 EAW78713 EAW78714 Q9UK58 AF180920 AAD53184 AF208843 AAF64257 AF367476 AAM21204 AF367477 AAM21205 AK022974 BAG51145 AK098021 AK122738 AK125606 AY034790 AAK61551 AY358663 AAQ89026 BC007081 AAH07081 BC038394 AAH38394 BC067812 AAH67812 BQ024284 BQ027163 BX641146 BX647554 JF432881 ADZ16098 XM_005247647 XP_005247704 XM_005247648 XP_005247705 XM_005247649 XP_005247706 XM_005247650 XP_005247707 XM_005247651 XP_005247708 XM_006713710 XP_006713773 XM_011513011 XP_011511313 NM_001308185 NP_001295114 NM_020307 NP_064703
Function Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036}.
Subcellular Location Nucleus speckle {ECO:0000250}. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.
Tissue Specificity Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036}.

cyclin L1 (C-19) - sc-33429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cyclin L1 (C-19): sc-33429. Western blot analysis of cyclin L1 expression in MCF7 nuclear extract.

cyclin L1 (C-15) - sc-33430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cyclin L1 (C-15): sc-33430. Western blot analysis of cyclin L1γ expression in HeLa nuclear extract (A) and SW480 (B) and COLO 320DM (C) whole cell lysates.

cyclin L1 (H-186) - sc-292385 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

cyclin L1 (A-16) - sc-33423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

cyclin L1 (N-15) - sc-33422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

cyclin L1 (Q-1) - sc-81843 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
cyclin L1 (Q-1): sc-81843 Western blot analysis of cyclin L1 expression in human cyclin L1 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-CCNL1 antibody - ab53045 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CCNL1 antibody (ab53045) at 1/500 dilutionLane 1 : HepG2 cell extractLane 2 : HepG2 cell extract with immunising peptide

Anti-CCNL1 antibody - ab68353 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
All lanes : Anti-CCNL1 antibody (ab68353) at 1 µg/mlLane 1 : CCNL1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-CCNL1 antibody - ab26253 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CCNL1 antibody (ab26253) at 2.5 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate (ab7900)

Anti-CCNL1 / Cyclin L1 Antibody (clone 1F7-1C5) - LS-C306788 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F7-1C5

Anti-CCNL1 / Cyclin L1 Antibody (aa32-81) - LS-C31235 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-CCNL1 / Cyclin L1 Antibody (aa105-154) - LS-C151188 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CCNL1 / Cyclin L1 antibody Western Blot of Rat Brain.

Anti-CCNL1 / Cyclin L1 Antibody (aa461-510) - LS-C118550 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2 cells, using Cyclin L1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CCNL1 / Cyclin L1 Antibody (aa350-400) - LS-C288818 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Cyclin L1 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Cyclin L1 used at a dilution of1:1000 (1 ug/ml). Detection: DAB.

Anti-CCNL1 / Cyclin L1 Antibody (aa350-400) - LS-C286718 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Cyclin L1 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Cyclin L1 used at a dilution of 1:500. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.

Anti-CCNL1 / Cyclin L1 Antibody (aa300-350) - LS-C288813 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Cyclin L1 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Cyclin L1 used at a dilution of1:1000 (1 ug/ml). Detection: DAB.

Anti-CCNL1 / Cyclin L1 Antibody (Glu491) - LS-C176172 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of Cyclin-L1 (E491) pAb in paraffin-embedded human breast carcinoma lung carcinoma tissue.

Anti-CCNL1 / Cyclin L1 Antibody (aa314-369) IHC-plus™ - LS-B79 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCNL1 / Cyclin L1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B79 concentration 20 ug/ml.

Anti-CCNL1 / Cyclin L1 Antibody IHC-plus™ - LS-B80 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCNL1 / Cyclin L1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B80 concentration 10 ug/ml.

CCNL1 Antibody - NBP1-77747 from Novus Biologicals

Prices $399.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CCNL1 Antibody [NBP1-77747] - Shows detection of a band ~35 kDa corresponding to Cyclin L b(arrowhead) present in mouse brain whole cell lysate (800 nm channel - green). Marker proteins appear red (700 nm channel) and were used for molecular weight comparisons. Approximately 35 ug of lysate was separated by 4-20% SDS-PAGE followed by transfer to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:2,500 for 2h at room temperature followed by washes and reaction with a 1:10,000 dilution of IRDye ™ 800 conjugated Gt-a-Rabbit IgG [H&L] MX for 45 min at room temperature.

CCNL1 Antibody - NBP1-78296 from Novus Biologicals

Prices $369.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CCNL1 Antibody [NBP1-78296] - Shows detection of a band ~59 kDa corresponding to a Cyclin L1a (arrowhead) present in mouse brain whole cell lysate. Approximately 35ug of lysate was separated by 4-20% SDS-PAGE followed by transfer to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:3,500 for 2h at room temperature followed by washes and reaction with a 1:10,000 dilution of IRDye (TM) 800 conjugated Gt-a-Rabbit IgG [H&L] MX for 45 min at room temperature.

EMI1 Antibody - NBP1-77748 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CCNL1 Antibody - H00057018-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: CCNL1 Antibody [H00057018-B01] - analysis of CCNL1 expression in transfected 293T cell line by CCNL1 MaxPab polyclonal antibody (B01). Lane 1: CCNL1 transfected lysate (59.60 KDa). Lane 2: Non-transfected lysate.

CCNL1 Antibody (1F7-1C5) - H00057018-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F7-1C5
Western Blot: CCNL1 Antibody (1F7-1C5) [H00057018-M01] - Analysis of CCNL1 expression in transfected 293T cell line by CCNL1 monoclonal antibody (M01), clone 1F7-1C5.Lane 1: CCNL1 transfected lysate(18 KDa).Lane 2: Non-transfected lysate.

Cyclin L Polyclonal Antibody - bs-7888R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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