SLC7A2
| Gene Symbol | SLC7A2 |
|---|---|
| Entrez Gene | 6542 |
| Alt Symbol | ATRC2, CAT2, HCAT2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
| Other Description | cationic amino acid transporter 2|low affinity cationic amino acid transporter 2 |
| Swissprots | B7ZL54 P52569 Q6NSZ7 O15292 Q86TC6 Q14CQ6 O15291 |
| Accessions | EAW63812 EAW63813 EAW63814 EAW63815 P52569 AA724796 AI275549 AI458117 AK314287 AL512749 AL832016 CAD89909 AU077312 BC069648 AAH69648 BC104905 AAI04906 BC113661 AAI13662 BC143583 AAI43584 CB216457 D29990 BAA06271 D78212 DB237902 U76368 AAB62810 U76369 AAB62811 XM_005273610 XP_005273667 XM_005273611 XP_005273668 XM_005273612 XP_005273669 NM_001008539 NP_001008539 NM_001164771 NP_001158243 NM_003046 NP_003037 |
| Function | Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:9174363}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:9174363}; Multi-pass membrane protein {ECO:0000269|PubMed:9174363}. |
| Tissue Specificity | Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart. {ECO:0000269|PubMed:8954799}. |
CAT-2 CRISPR/Cas9 KO Plasmid (h) - sc-407551 from Santa Cruz Biotechnology
|
||||||||
CAT-2 HDR Plasmid (h) - sc-407551-HDR from Santa Cruz Biotechnology
|
||||||||
CAT-2 Double Nickase Plasmid (h) - sc-407551-NIC from Santa Cruz Biotechnology
|
||||||||
CAT-2 Double Nickase Plasmid (h2) - sc-407551-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CAT-2 CRISPR Activation Plasmid (h) - sc-407551-ACT from Santa Cruz Biotechnology
|
||||||||
CAT-2 CRISPR Activation Plasmid (h2) - sc-407551-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CAT-2 Lentiviral Activation Particles (h) - sc-407551-LAC from Santa Cruz Biotechnology
|
||||||||
CAT-2 Lentiviral Activation Particles (h2) - sc-407551-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CAT-2 siRNA (h) - sc-77441 from Santa Cruz Biotechnology
|
||||||||
CAT-2 shRNA Plasmid (h) - sc-77441-SH from Santa Cruz Biotechnology
|
||||||||
CAT-2 shRNA (h) Lentiviral Particles - sc-77441-V from Santa Cruz Biotechnology
|
||||||||
SLC7A2 RNAi - H00006542-R01 from Novus Biologicals
|
||||||||
SLC7A2 RNAi - H00006542-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU060671 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19687 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19687 from Sigma-Aldrich
|
||||||||
SLC7A2 siRNA (Human) - CRH4435 from Cohesion Biosciences
|
||||||||
SLC7A2 - MBS8236205 from MyBioSource
|
||||||||
shRNA set against Human SLC7A2 (NM_003046.5) - SHH412104 from Creative biogene
|
||||||||
SLC7A2 shRNA Plasmid (Human) - CHH4435 from Cohesion Biosciences
|