Gene Symbol | SLC7A2 |
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Entrez Gene | 6542 |
Alt Symbol | ATRC2, CAT2, HCAT2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
Other Description | cationic amino acid transporter 2|low affinity cationic amino acid transporter 2 |
Swissprots | B7ZL54 P52569 Q6NSZ7 O15292 Q86TC6 Q14CQ6 O15291 |
Accessions | EAW63812 EAW63813 EAW63814 EAW63815 P52569 AA724796 AI275549 AI458117 AK314287 AL512749 AL832016 CAD89909 AU077312 BC069648 AAH69648 BC104905 AAI04906 BC113661 AAI13662 BC143583 AAI43584 CB216457 D29990 BAA06271 D78212 DB237902 U76368 AAB62810 U76369 AAB62811 XM_005273610 XP_005273667 XM_005273611 XP_005273668 XM_005273612 XP_005273669 NM_001008539 NP_001008539 NM_001164771 NP_001158243 NM_003046 NP_003037 |
Function | Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:9174363}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:9174363}; Multi-pass membrane protein {ECO:0000269|PubMed:9174363}. |
Tissue Specificity | Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart. {ECO:0000269|PubMed:8954799}. |
CAT-2 (S-13) - sc-87038 from Santa Cruz Biotechnology
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CAT-2 (C-17) - sc-87036 from Santa Cruz Biotechnology
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Anti-SLC7A2 antibody - ab64896 from Abcam
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Anti-SLC7A2 antibody - ab133368 from Abcam
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Anti-SLC7A2 Antibody (aa612-632) IHC-plus™ - LS-B901 from LifeSpan Bioscience
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Anti-SLC7A2 Antibody (C-Terminus) IHC-plus⢠- LS-A9309 from LifeSpan Bioscience
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Anti-SLC7A2 Antibody (Internal) IHC-plus⢠- LS-A9306 from LifeSpan Bioscience
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Anti-SLC7A2 Antibody (aa215-264) - LS-C110817 from LifeSpan Bioscience
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Anti-SLC7A2 Antibody (aa608-658) - LS-C291081 from LifeSpan Bioscience
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SLC7A2 Antibody - NBP1-59872 from Novus Biologicals
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SLC7A2 Antibody - NBP1-88909 from Novus Biologicals
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SLC7A2 Antibody - NBP1-02524 from Novus Biologicals
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Anti-SLC7A2 antibody produced in rabbit - HPA009169 from Sigma-Aldrich
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Anti-SLC7A2 antibody produced in rabbit - SAB2900690 from Sigma-Aldrich
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Anti-SLC7A2 antibody produced in rabbit - SAB2105528 from Sigma-Aldrich
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SLC7A2 antibody - middle region (ARP43766_P050) - ARP43766_P050 from Aviva Systems Biology
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SLC7A2 Antibody (OALA01501) - OALA01501 from Aviva Systems Biology
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SLC7A2 Antibody (OALA01502) - OALA01502 from Aviva Systems Biology
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SLC7A2 antibody - 70R-6789 from Fitzgerald
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SLC7A2 / CAT2 (612-632) antibody - AP07973PU-N from Acris Antibodies
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Rabbit Anti-Human SLC7A2 (aa612-632) - 119-11904 from RayBiotech
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Rabbit Anti-Human SLC7A2 (Internal) - 119-17480 from RayBiotech
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Rabbit Anti-Human SLC7A2 (C-Terminus) - 119-17481 from RayBiotech
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SLC7A2 Antibody - 49-731 from ProSci
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SLC7A2 Antibody - 71-086 from ProSci
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