Gene Symbol | CINP |
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Entrez Gene | 51550 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cyclin-dependent kinase 2 interacting protein |
Other Description | CDK2-interacting protein|cyclin-dependent kinase 2-interacting protein |
Swissprots | Q9NPF9 F5H8A7 F5H7P3 Q9BW66 |
Accessions | EAW81785 EAW81786 Q9BW66 AF228148 AAF44747 AF228149 AAF44748 AK056112 BAB71095 BC000600 AAH00600 BU174070 BX248279 CAD62607 CR457178 CAG33459 DA167716 DA351468 DA699021 EL951117 XM_005267753 XP_005267810 XM_011536830 XP_011535132 XM_011536831 XP_011535133 NM_032630 NP_116019 NM_001177611 NM_001177612 |
Function | Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19889979}. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. |
CINP CRISPR/Cas9 KO Plasmid (h) - sc-417126 from Santa Cruz Biotechnology
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CINP HDR Plasmid (h) - sc-417126-HDR from Santa Cruz Biotechnology
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CINP Double Nickase Plasmid (h) - sc-417126-NIC from Santa Cruz Biotechnology
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CINP Double Nickase Plasmid (h2) - sc-417126-NIC-2 from Santa Cruz Biotechnology
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CINP CRISPR Activation Plasmid (h) - sc-417126-ACT from Santa Cruz Biotechnology
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CINP CRISPR Activation Plasmid (h2) - sc-417126-ACT-2 from Santa Cruz Biotechnology
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CINP Lentiviral Activation Particles (h) - sc-417126-LAC from Santa Cruz Biotechnology
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CINP Lentiviral Activation Particles (h2) - sc-417126-LAC-2 from Santa Cruz Biotechnology
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CINP siRNA (h) - sc-92209 from Santa Cruz Biotechnology
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CINP shRNA Plasmid (h) - sc-92209-SH from Santa Cruz Biotechnology
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CINP shRNA (h) Lentiviral Particles - sc-92209-V from Santa Cruz Biotechnology
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CINP RNAi - H00051550-R02 from Novus Biologicals
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MISSION® esiRNA - EHU072111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6136 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6136 from Sigma-Aldrich
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CINP siRNA (Human) - CRH9826 from Cohesion Biosciences
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CINP - MBS826901 from MyBioSource
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shRNA set against Human CINP (NM_032630.2) - SHH264121 from Creative biogene
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shRNA set against Human CINP(NM_032630.2) - SHG169885 from Creative biogene
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Human CINP siRNA - orb270328 from Biorbyt
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CINP shRNA Plasmid (Human) - CHH9826 from Cohesion Biosciences
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CINP miRNA 3'UTR clone - MiUTR1H-02169 from Creative biogene
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