| Gene Symbol |
CTR9
|
| Entrez Gene |
9646
|
| Alt Symbol |
SH2BP1, TSBP, p150, p150TSP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTR9, Paf1/RNA polymerase II complex component
|
| Other Description |
Ctr9, Paf1/RNA polymerase II complex component, homolog|RNA polymerase-associated protein CTR9 homolog|SH2 domain binding protein 1 (tetratricopeptide repeat containing)|SH2 domain-binding protein 1|TPR-containing, SH2-binding phosphoprotein
|
| Swissprots |
D3DQV8 Q15015 Q6PD62
|
| Accessions |
CCQ43449 EAW68557 EAW68558 Q6PD62 AK291794 BAF84483 BC014335 BC058914 AAH58914 BP223102 BP250198 D63875 BAA09925 NM_014633 NP_055448
|
| Function |
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
|
| Subcellular Location |
Nucleus speckle {ECO:0000250}. Note=Found in speckles. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:8590280}.
|