CTR9

Gene Symbol CTR9
Entrez Gene 9646
Alt Symbol SH2BP1, TSBP, p150, p150TSP
Species Human
Gene Type protein-coding
Description CTR9, Paf1/RNA polymerase II complex component
Other Description Ctr9, Paf1/RNA polymerase II complex component, homolog|RNA polymerase-associated protein CTR9 homolog|SH2 domain binding protein 1 (tetratricopeptide repeat containing)|SH2 domain-binding protein 1|TPR-containing, SH2-binding phosphoprotein
Swissprots D3DQV8 Q15015 Q6PD62
Accessions CCQ43449 EAW68557 EAW68558 Q6PD62 AK291794 BAF84483 BC014335 BC058914 AAH58914 BP223102 BP250198 D63875 BAA09925 NM_014633 NP_055448
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus speckle {ECO:0000250}. Note=Found in speckles. {ECO:0000250}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:8590280}.

CTR9 Antibody Blocking Peptide - LS-E23586 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CTR9-Antibody-Center-Blocking-Peptide - BP8853c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CTR9 fusion protein - ag8076 from Proteintech Group

Category Protein
Source E. coli-derived, T-HIS
Species Human

CTR9 fusion protein - ag15690 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human RNA polymerase-associated protein CTR9 homolog(CTR9) ,partial - CSB-YP750854HU CSB-EP750854HU CSB-BP750854HU CSB-MP750854HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CTR9 Recombinant Protein Antigen - NBP2-49547PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E. coli
Species Human

CTR9 Peptide, Human - M34GP03810H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

RNA polymerase-associated protein CTR9 homolog (CTR9), partial, Recombinant Protein - MBS1424291 from MyBioSource

Category Protein
Prices $835.00, $950.00, $1,055.00, $1,170.00, $1,170.00, $1,390.00, $1,620.00, $1,850.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CTR9 Recombinant Protein Antigen - NBP2-57251PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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